Independent component analysis (ICA) was used as a blind source separation method on a Raman image of a pharmaceutical tablet. Calculations were performed without a priori knowledge concerning the formulation. The aim was to extract the pure signals from the initial data set in order to examine the distribution of actives and major excipients within the tablet. As a method based on the decompos...

Hydrophilic matrix tablets (matrices) for oral use are designed to hydrate on swallowing, and form a ‘gel’ layer of hydrated polymer at the tablet surface to control the rate of drug release during passage of the matrix through the gastrointestinal tract. During gastrointestinal transit, the matrices are reduced in size through surface erosion and dissolution. This reduces the probability of ex...

Development of a lyophilized orally disintegrating tablet (ODT) that enhanced the in vitro dissolution and in vivo absorption of nimesulide (NM), a drug with poor solubility and poor bioavailability, is presented. The ODTs were prepared by freeze-drying an aqueous dispersion of NM containing a matrix former, a sugar alcohol, and a collapse protectant. In addition, different disintegration accel...

Many novel pharmaceutically active substances are characterized by a high hydrophobicity and a low water solubility, which present challenges for their delivery as drugs. Tablets made from cross-linked hydrophobically modified poly (acrylic acid) (CLHMPAA), commercially available as Pemulen™, have previously shown promising abilities to control the release of hydrophobic model substances. This ...

Colon targeted tablet formulation was developed using okra polysaccharide (Abelmuschus esculentus) as a microbially triggered material and also as the carrier. Okra polysaccharide was isolated from Abelmuschus esculentus and used for tablet formulation with Ibuprofen as model drug. The matrix tablets with four different proportions of the okra (20%, 30%, 40% & 50%) with 1% ethyl cellulose in al...