DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalconecompound. In this study, its antidepressant-like activity of compound DHIPC was evaluated bythe forced swimming test and the tail suspension test in mice. The results showed that DHIPCsignificantly reduced the immobility time for 2 h after treatment through the oral administrationat dose of 10, 20, and 30 mg/kg in th...

Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Am...

introduction: celastrus paniculatus seed oil, commonly known as malkangni or jyotishmati, was in use from time immemorial to treat brain related disorders. celastrus paniculatus seed oil has significant antidepressant-like activity in chronic unpredictable stressed mice. the present study was undertaken to evaluate the antidepressant-like effect of celastrus paniculatus seed oil in unstressed m...

DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalconecompound. In this study, its antidepressant-like activity of compound DHIPC was evaluated bythe forced swimming test and the tail suspension test in mice. The results showed that DHIPCsignificantly reduced the immobility time for 2 h after treatment through the oral administrationat dose of 10, 20, and 30 mg/kg in th...

In generally, a suspension system needs to be soft to insulate against road disturbances and hard to insulate against load disturbances. It cannot achieve with a traditional passive suspension that only considered to the stiffness and damper. In this study, the paper clarifies some issues related to suspension system with inerter to reduce sprung mass displacement and tire deflection in quarter...

The document was approved by the American College of Cardiology Board transparency, disclosure information for the ACC Board of Trustees, the boa www.acc.org/about-acc/leadership/officers-and-trustees. The American College of Cardiology requests that this document be cited as Freeman R, McPherson JA, Mendes LA, Ryan T, Sivaram CA, Weitz HH. 2016 the ACC Competency Management Committee. J Am Col...