BACKGROUND Mast cells (MCs) are widely distributed in the gastrointestinal tract, which could be involved in visceral hypersensitivity and gut dysmotility. Whether esophageal MCs play a role in non-erosive reflux disease (NERD) has yet to be determined. The aim of this study was to characterize esophageal MCs distribution, degranulation, and ultrastructure. METHODS The esophageal mucosa at 5 ...

The point of departure of this paper is the agenda for further research advanced by Langfield-Smith (1997) in her critique of studies investigating the relationship between management control systems (MCS) and strategy. In considering the ways in which subsequent MCS-strategy research has advanced our knowledge according to Langfield-Smith’s initial observations, the present paper proposes a re...

OBJECTIVES Recent analyses establish that heart transplantation is increasing among adults with congenital heart disease (ACHD), but the effects of pretransplant mechanical circulatory support (MCS) on perioperative and post-transplant outcomes have not been examined in the ACHD population. METHODS Scientific Registry of Transplant Recipients data on all adult heart transplants from September...

BACKGROUND Medial clear space (MCS) width on mortise radiographs of the ankle is commonly used by clinicians for determining the competence of the deltoid ligament in the Weber B supination-external rotation ankle fracture. Significant variability exists in the current literature regarding methods of obtaining this measure and definition of a normal measure in comparison with a pathologic state...

Management Control System (MCS) research is undergoing turbulent times. For a long time related to cybernetic instruments of management accounting only, MCS are increasingly seen as complex systems comprising not only formal accountingdriven instruments, but also informal mechanisms of control based on organizational culture. But not only have the means of MCS changed; researchers increasingly ...

In the healthy mammalian CNS, mast cells (MCs) are thought to be located mostly in the thalamus. In this study, we have systematically assessed the presence of MCs in the hippocampal formation (HF) and in the thalamus of normal male and female B10.PL mice. Giemsa(+) and Toluidine Blue(+) MCs were detected by histomorphometric analyses at perivascular and intraparenchymal sites of both the hippo...

A mutual spatial and functional relationship occurs between mast cells (MCs) and endothelial cells and the density of MCs is highly correlated with the extent of tumor angiogenesis. The aim of this study was to investigate the pattern of MCs around the blood vessels in melanoma samples by means of an approach derived from spatial statistics, based on the analysis of the distribution of the dist...

objective(s) human umbilical cord blood (hucb) is now considered as a valuable source for stem cell–based therapies. previous studies showed that intravascular injection of the hucb significantly improves neurological functional recovery in a rat model of intracerebral hemorrhage (ich). in the present study, we hypothesize transplanted hucb derived mononuclear cells (uc-mcs) can decrease injure...

STUDY DESIGN A prospective genetic association study. PURPOSE The etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking, and candidate genes involved in other disc degeneration phenotypes have not been evaluated. We studied the prevalence of MCs and genetic associat...

The activation of presynaptic histamine 3 (H(3)) receptors inhibits the release of histamine and other neurotransmitters from central nervous system neurons. Rat brain mast cells (MCs) release histamine and 5-hydroxytryptamine (5-HT) in response to neuropeptides and neurotransmitters secreted from adjacent neurons. Dura MCs also degranulate in response to antidromic trigeminal nerve stimulation...