This position paper reports on an initial investigation in the fields of MDA and generative approaches. Our view is that MDA aims at providing a precise framework for generative software production. Unfortunately many notions are still loosely defined (PIM, PSM, etc.).. We propose here an initial exploration of some basic artifacts of the MDA space. Because all these artifacts may be considered...

The paper presents Ontology Definition Metamodel (ODM) and Ontology UML Profile that enables using Model Driven Architecture (MDA) standards in ontological engineering. Other similar metamodels are based on ontology representation languages, such as RDF(S), DAML+OIL, etc. However, none of these other solutions uses the recent W3C effort – The Web Ontology Language (OWL). In our approach, we fir...

4 Wagner JC. Asbestos dust exposure and malignancy. Proceedings of 14th congress on occupational health. Madrid: 1963. 5 Hourihane DO'B, Lessof L, Richardson PC. Hyaline and calcified pleural plaques as an index of exposure to asbestos. A study of radiological and pathological features of 100 cases with the consideration of epidemiology. Biological monitoring of MDA Sir,-4,4'-methylenedianiline...

In this report, we describe the case of a patient who has remained in a comatose state for more than one year after a traumatic and hypoxic brain injury. This state, which we refer to as long-lasting coma (LLC), may be a disorder of consciousness with significantly different features from those of conventional coma, the vegetative state, or brain death. On the basis of clinical, neurophysiologi...

α-Synuclein (α-syn) plays a prominent role in the degeneration of midbrain dopaminergic (mDA) neurons in Parkinson's disease (PD). However, only a few studies on α-syn have been performed in the mDA neurons in vivo, which may be attributed to a lack of α-syn transgenic mice that develop PD-like severe degeneration of mDA neurons. To gain mechanistic insights into the α-syn-induced mDA neurodege...

In the present study we show that histone deacetylase inhibitors (HDACIs) enhance the anti-tumor effects of melanoma differentiation associated gene-7/interleukin 24 (mda- 7/IL-24) in human renal carcinoma cells. Similar data were obtained in other GU tumor cells. Combination of these two agents resulted in increased autophagy that was dependent on expression of ceramide synthase 6, with HDACIs...

The Model Driven Architecture (MDA) involves automated transformations between software models defined in different languages at different abstraction levels. This paper takes an MDA approach to integrate a formal modeling language (Object-Z) with an informal modeling language (UML) via model transformation. This paper shows how formal and informal modeling languages can be cooperatively used i...

Lymphatic filariasis is one of the neglected tropical diseases. It is estimated that 120 million people are currently infected in 73 countries where filariasis is endemic. Lymphatic filariasis is a leading cause of chronic disability worldwide, including of 15 million people who have lymphoedema (elephantiasis) and 25 million men who have hydrocoele.

The history of software engineering is marked by ever-rising levels of abstraction. The first programmers coded in binary; in short order, the field moved to assembly language, then 3GLs such as Fortran and Cobol, and now the effort involves more expressive traditional languages (such as C++ and Java) as well as domain-specific 4GLs. Development environments, originally command-line tools, inte...

For developing large and complex applications, industrial practice uses a combination of nonformal notations and methods. Different notations are used to specify the properties of different aspects of an application and these specifications are transformed into their corresponding implementations through the steps of a development process. The development process relies heavily on manual verifi...