Weshow that repulsive local Coulomb interaction alone can drive valence-skipping charge disproportionation in the degenerate d-band, resulting in effective negative-U . This effect is shown to originate from anisotropic orbitalmultipole scattering, and it occurs only for d1, d4, d6, and d9 fillings (and their immediate surroundings). Explicit boundaries for valence-skipping are derived, and the...

Germline mutations in the DNA mismatch repair genes MSH2 and MLH1 are responsible for the majority of hereditary nonpolyposis colorectal cancer (HNPCC) families. A common mutation mechanism is to disrupt MLH1 and MSH2 mRNA splicing. The disruption creates aberrant mRNAs lacking specific coding exons (exon skipping). Here, we report a novel skipping of MLH1 exon 12 caused by an AAG to TAG nonsen...

A readily available animal model is essential for rapidly identifying effective treatments for Duchenne muscular dystrophy (DMD), a devastating neuromuscular disorder caused by the lack of dystrophin protein, which results from frame-disrupting mutations in the DMD gene. Currently, the mdx mouse is the most commonly used model for antisense oligonucleotide (AO)-mediated exon skipping pre-clinic...

Ubiquitin specific protease 4 (USP4) is a highly networked deubiquitinating enzyme with reported roles in cancer, innate immunity and RNA splicing. In mammals it has two dominant isoforms arising from inclusion or skipping of exon 7 (E7). We evaluated two plausible mechanisms for the generation of these isoforms: (A) E7 skipping due to a long upstream intron and (B) E7 skipping due to inefficie...

Bone mineral accrual during puberty is important, especially in girls, because it is related to reduced risks of osteoporosis in adulthood. Previous research has shown that jumping or plyometric exercises may be effective in increasing bone mineral density in adolescents. Rope skipping is a form of activity that involves jumping, thus regular skipping may also increase bone mineral density in p...

It is well known that one can skip a stone across the water surface, but less well known that a ball can also be skipped on water. The Waboba R © is an elastic ball used in a game of aquatic keep away in which players pass the ball by skipping it along the water. We investigate the physics of skipping elastic balls to elucidate the mechanisms by which they bounce off water. High speed video rev...

Duchenne muscular dystrophy (DMD), the most common muscle degenerative disease, is an X-linked genetic disorder caused by loss or reduction of dystrophin protein, resulting in progressive wasting, and involving skeletal, cardiac, respiratory muscles. There currently no cure for DMD, anti-inflammatory steroid conventional treatment to delay disease progression. Recently, several therapeutic appr...

Trace monitor specifications consist of a pattern that is matched against the trace of events of a subject system. We investigate the design choices in defining the semantics of matching patterns against traces. Some systems use an exact-match semantics (where every relevant event must be matched by the pattern), while others employ a skipping semantics (which allows any event to be skipped dur...

the experiment was to study the effects of replacing soybean meal by rubber seed meal on growth, economics and carcass characteristics of broiler. a total of 150 day-old commercial broiler (cobb-500) was reared for a period of 35 days. there were five treatments including t0 (without rubber seed meal), t1 (10% rubber seed meal), t2 (20% rubber seed meal), and t3 (30% rubber seed meal) and t4 (4...