an important concern in rock mechanics is non-homogeneity as joints or fault. this noticeable feature of failures in rock is appearance of slip surfaces or shear bands, the characteristics of that are associated with deformation being concentrated in a narrow zones and the surrounding material remaining intact. adopting the joints as fractures, fractures are well known for their effects on the ...

objective(s): nowadays, cardiovascular diseases (cvds) are the major risk factors of death globally. one of the most undeniable reasons of cvds is metabolic syndrome (mets). mets is defined as a complex of diseases including insulin resistance, hyperglycemia, obesity, high blood pressure and dyslipidemia. the use of complementary medicine such as traditional herbal species can be effective in t...

background: one of the new methods for elimination or destruction of estrogen hormones is ultrasound irradiation. the aim of this study was to determine the main mechanism of steroid hormones removal by ultrasound. methods: in this study, estrogen (e1) and 17 beta-estradiol (e2) were irradiated with ultrasound at different frequencies, powers, and exposure times in two cases: with and without b...

hariri’s maqamat is one of arabic cultural and literary works in the field of social aspects of life and linguistic characteristics and language games, as well as on narrative aspects of fictions. avoidance from pure verbal and historical topics and from mere attention to rhetorical techniques in this work, on one hand, and the tendency to survey and follow the narration on the other hand can p...

a new type of backbone robot is presented in this paper. the core idea is to use a cross shape mechanism with the principle of functioning of the scissors linkages, known as a pantograph. although this continuum arm acts quite similar to tendon-driven robot, this manipulator does not include any tendon in its structure. this design does not suffer from the weaknesses of the continuum design suc...

objective(s): we previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. in this study, we investigated the mechanism underlying the anti-angiogenic activity of the quinazoline derivative compound 11d. materials and methods: we examined the effects of quinazoline derivative 11d on vascular endothelial growth factor receptor-2 (vegfr2) activation via vegf...

the toxicity of chlorpyrifos to three iranian populations of two-spotted spider mite, collected from isfahan (isr), yazd (yz) and guilan (gus2) provinces were surveyed using the residual contact vial bioassay. the bioassay results showed that resistance ratios of isr and yz populations were 176.90 and 9.78 fold compared to the gus2 population, respectively. determination of esterase and glutath...

as a generalization of the triple i method, the universal triple imethod is investigated from the viewpoints of both fuzzy reasoningand fuzzy controller. the universal triple i principle is putforward, which improves the previous triple i principle. then,unified form of universal triple i method is established based onthe (0,1)-implication or r-implication. moreover, the reversibilityproperty o...

aggregation of pharmaceutical proteins reduces the efficiency and increases the cost of production. it can also lead to the reduced efficacy of drug or cause side effects on the patient’s body. investigating how to create them plays an important role to find agents that prevents the aggregation. this study was allocated for understanding the mechanism of formation of the reteplase protein using...

the aim of the present study was to investigate the influence and the mechanisms of cineoleand terpineol on the in-vitro transdermal delivery of huperzine a from microemulsions, andtheir potential synergistic effect on the permeation enhancement. the transdermal deliveryof huperzine a from microemulsions with different concentrations of cineole and terpineolthrough the rat abdominal skin was de...