Abstract Background Malignant lymphoma accounts for nearly 20% of all mediastinal neoplasms in adults and 50% children. Hodgkin’s disease is the most common primary lymphoma. In non-Hodgkin’s lymphoma, two forms are lymphoblastic diffuse large B-cell The aim this study to implement diffusion MRI algorithm diagnosis differentiating Hodgkin's from non-Hodgkin's assessment post therapeutic respons...

Endoscopic submucosal dissection (ESD) enables wider tumor resection compared with endoscopic mucosal resection and en bloc resection of superficial esophageal neoplasms. However, ESD may cause difficult-to-treat stricture of the esophagus, and therefore, prediction of and measures against postoperative esophageal stricture are critical. The aim of this study was to evaluate the effect of ESD o...

Mediastinal liposarcoma (ML) is a rare mesenchymal tumor, accounting for less than 1% of mediastinal tumors. They have a slow growth, so they may not give symptoms for a long time, until the tumor produces compression of close structures. The treatment of choice is surgery, which can be combined with chemo-radiotherapy. We present a case in which the diagnosis of a ML was made in a 30-year-old ...

BACKGROUND Atypical carcinoid arising from the mediastinal tissue is a rare neuroendocrine tumor and an association with parathyroid adenoma is very unusual. We report an unusual case of atypical carcinoid of mediastinum with metastasis in a patient presenting with parathyroid adenoma, which is the first case to be reported from Pakistan. CASE PRESENTATION A 51-year-old Pakistani man was seen...

BCL-6 mutations are accumulated during B-cell transit through the germinal center (GC) and provide a histogenetic marker for B-cell tumors. On the basis of a comprehensive analysis of 308 B-cell neoplasms, we (1) expand the spectrum of tumors associated with BCL-6 mutations; (2) corroborate the notion that mutations cluster with GC and post-GC B-cell neoplasms; and (3) identify heterogeneous mu...

there has been a highly significant increase in the number of patients with malignant mediastinal tumors in the last four decades. since these lesions are infrequently encountered and there are very few reports in iran concerning this issue, we performed this study to review our institutional experience of medias-tinal masses and to compare differences in the clinical spectrum between our study...

Teratoma is a common tumour of the mediastinum but is rarely found in the lung. The twentieth reported case was published in 1975 by Day and Taylor and four cases have been published since.'-5 A rare condition, not previously recorded, was observed by us in a young male patient. He was found to have a mediastinal teratoma, which was followed 10 years later by the growth of an intrapulmonary ter...

Numerous disorders can cause precocious puberty in children, and germ cell tumours (GCT) are one of the rare causes . We report two cases of mediastinal malignant GCTs who presented with precocious puberty. Both patients had bulky and advanced disease, were aggressively treated with neo-adjuvant chemotherapy and surgery, and are surviving and free of disease.

Germ cell tumors (GCTs) are a heterogeneous group of neoplasms that arise from the primordial germ cells human embryo, which normally destined to produce reproductive sperm, or ova. GCTs can be present in both gonadal and extragonadal GCT sites. Pediatric relatively rare with an incidence 2%-3%. Primary mediastinal very anterior mediastinum. In this report, we case 16-year-old boy primary semin...