We performed a multicenter assessment of a new HER2 dual-color chromogenic in situ hybridization (CISH) test and herein report on concordance of CISH data with fluorescence in situ hybridization (FISH) data and intraobserver and interlaboratory scoring consistency. HER2 results were evaluated using duplicate cores from 30 breast cancers in 5 laboratories using the Ventana HER2 dual-color ISH as...

In many laboratories, microscopy still remains the cornerstone of parasitological diagnostics and provides an epidemiological assessment parasite burden. High-quality diagnostic service includes participation in external quality assurance (EQA) scheme to help measure service. This presentation will review laboratories' performance liquid EQA programs offered by RCPAQAP. Results for different st...

Computerized Motion Diagnostic Imaging (CMDI) Systems (Motion Diagnostics Laboratories, Hauppauge, NY) employ a dual-inclinometer and/or a long-arm goniometer and computer software to track range of motion and can allegedly estimate the percentage of impairment of the spine. However, there is a lack of evidence in the published peer-reviewed medical literature to support the usefulness of these...

Mutation detection plays an increasingly significant role in clinical diagnostic testing, posing formidable challenges for laboratories. The expanding indications for clinical molecular testing and the nuances of interpreting test results are discussed. Methods for screening mutation detection platforms and monitoring assay reliability are presented, and results of platform comparisons are desc...