skin and hair, and is synthesized in melanosomes transferred from melanocytes. Although melanin plays an important protective role against UV light, over production and accumulation of melanin pigment it could create serious skin problems such as freckles, age spots, and melasma. Thus, the inhibition of melanogenesis has been the focus of medicinal and cosmetic treatments for skin depigmenting ...

Fairer skin is preferred in many Asian countries and there a high demand for whitening lightening products. However, recent years, problems related to the safety of using agents have emerged. This study demonstrates that plant-derived scutellarein effectively inhibits melanogenesis B16 melanoma cells. baicalein, which similar its chemical structure, does not show any inhibitory effect on melano...

Vitamin D plays a role in the process of melanogenesis, namely increasing L-Dopa cells, inducing differentiation immature melanocytes, and melanocyte activity. The use vitamin dermatology is treatment vitiligo, psoriasis vulgaris, atopic dermatitis, verruca alopecia. Vitiligo an autoimmune disease skin form depigmentation due to destruction melanocytes by T cells. clinical manifestations vitili...

cAMP signaling is well-established in the regulation of melanin synthesis. Two distinct pathways, melanocortin 1 receptor (MC1R) and soluble adenylyl cyclase (sAC) are known to differentially modulate melanogenesis. The MC1R pathway control melanogenesis via gene expression, while sAC influences synthesis melanosomal pH. However, whether affects pH remained unclear. Using human mouse melanocyte...