Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. Objective: To assess whether multiple ...

Cutaneous malignant melanoma is a type of skin cancer that you can die from. The number patients being diagnosed with the rising in most countries. About 4000 were Sweden 2018. risk dying from cutaneous very much dependent on thickness melanoma, measure given by pathologist after removing melanoma. increases increasing thickness. Most who are will have thin melanomas, i.e. 1 mm or thinner.

background: malignant melanoma is a highly aggressive malignant melanocytic neoplasm which resists against the most conventional therapies. sea cucumber as one of marine organisms contains bioactive compounds such as polysaccharide, terpenoid and other metabolites which have anti-cancer, anti-tumor, anti-inflammatory and antioxidant properties. the present study was designed to investigate the ...

purpose: to design and manufacture iodine 125 radioactive plaques which can be used in patients with ocular melanoma, and to evaluate the efficacy of plaques in an animal model. methods: this prospective basic study was performed in collaboration with farabi hospital and tehran atomic energy agency. the iodide 125 plaques were designed and manufactured based on the collaborative ocular melanoma...

background: recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. in spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. in the presented work, the effect of utilizing an eye model with ocular media on pr...

The consideration of systemic adjuvant therapy is recommended for patients with stage IIB-IV melanoma who have undergone surgical resection due to a heightened risk experiencing relapse and mortality from melanoma. Adjuvant options tested over the past three decades include high-dose interferon-α, immune checkpoint inhibitors (pembrolizumab, nivolumab), targeted (dabrafenib-trametinib BRAF muta...

Abstract Although identified as the key environmental driver of common cutaneous melanoma, role ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 melanomas conjunctival origin by whole genome sequencing and our data shows a predominance UVR-associated single base substitution signature 7 (SBS7) majority samples. Our with SBS7 dominance have simi...

nepeta satureioides boiss. has been used in traditional medicine of eastern countries and is famous for its medicinal properties. the aim of this study was to evaluate the effect of methanol (meoh), n -hexane and dichloromethane (ch 2 cl 2 ) fractions of the extract on melanin synthesis and oxidative stress in b16f10 melanoma cell line. the b16f10 cell line viability after treatment with increa...

background: fusion of dendritic cells (dcs) with melanoma cells could reinforce the antigenicity of tumors as a strategy for the treatment of malignant melanoma. however, the insufficient quantity of dcs and the low fusion efficiency limits the development of such approach. objective: to define the dosage of the stimulating factors as well as the induction condition for the optimal dcs preparat...

Sun exposure is widely recognized as the primary etiology of cutaneous melanoma. However, melanomas also occur in skin areas unexposed to sun, such palmoplantar surface. Little known about risk factors and mutational processes acral melanoma; however, they frequently at points higher mechanical stress on hand foot, suggesting a contributing factor for plantar melanoma development. Furthermore, ...