Background and objectives: Curcumin as a medicinal substance has shown effective in different kinds of diseases especially cancer. To understand its underlying mechanism, molecular complementary study of differentially expressed microRNAs (DEMs) could assist. In this view, regulatory network analysis of DEMs of melanoma cancer treated with curcumin versus the untreated male <em...

OBJECTIVE To understand the risk of cutaneous melanoma (CM) following a previous cancer. DESIGN Using the Surveillance, Epidemiology, and End Results database (1988-2007), we compared a cohort of patients diagnosed as having CM as a first cancer with a cohort of patients diagnosed as having CM following a previous cancer. PARTICIPANTS We included 70,819 patients with CM as a first primary c...

Both cell-autonomous and non–cell-autonomous factors contribute to tumor growth and metastasis of melanoma. The function of caveolin-1 (Cav1), a multifunctional scaffold protein known to modulate several biologic processes in both normal tissue and cancer, has been recently investigated inmelanoma cancer cells, but its role in the melanoma microenvironment remains largely unexplored. Here, we s...

Plasminogen activating inhibitor-1 (PAI-1) is associated with poor clinical outcomes in cancer patients, and elevated levels of PAI-1 both tissue serum are correlated response to therapy various cancers, including skin cancer. reported as a key regulator PD-L1 expression on melanoma cells through endocytosis, leading abrogating the efficacy anti-PD1 antibodies (Abs). These findings suggested th...

In this paper, we have presented a new technique for classification of skin cancer using back-propagation training techniques. — Skin cancer is the deadliest form of cancers in humans. Skin cancer is commonly known as Melanoma. Melanoma is named after the cell from the melanocyte. Skin Cancers are of two typesBenign and Malignant Melanoma. The system is tested on skin dataset of skin cancer ima...

Skin is important organ of our body which covers muscles, bones, and other parts body. Melanoma a kind skin cancer that begins in melanocytes cell. It can influence on the only, or it may expand to bones organs. less common, but more serious aggressive than types cancer. Majority deaths related occur due over world. For effective treatment very melanoma identified earlier as possible. As well d...

Skin cancer is one of the most frequent cancer, accounting for about half all diagnoses globally. Melanoma a skin that arises from melanocytes, which are pigment-producing cells. occurrence and fatality rates have risen dramatically in recent years. Early detection can assist medical experts treating disease attracted diverse researchers. This article focuses on different segmentation technique...

Skin cancer includes melanoma and basal and squamous cell carcinoma. Basal and squamous cell carcinoma, known together as nonmelanoma skin cancer, are the most common types of cancer in the United States and represent the vast majority of all cases of skin cancer (> 98%).1 However, nonmelanoma skin cancer rarely results in death or substantial morbidity (< 0.1% of patient deaths are caused by t...

Our study aimed to explore the unknowns regarding absolute and relative risks of future skin cancers in patients with actinic keratoses(AKs). We performed a retrospective cohort using de-identified, random sample 4,999,999 fee-for-service Medicare beneficiaries aged ≥65 years (2009-2018). included treated AKs and, as comparator group, benign lesion seborrheic keratosis(SK). Both groups required...