In the United States, skin cancer is the most common type of cancer, which is further divided into three types of cancer: basal cell, squamous cell and melanoma. Basal cell and squamous cell cancers are the most common types of skin cancer, but they are less deadly and more readily treated than melanoma. While it is the least common of the skin cancers, more than 68,000 Americans are diagnosed ...

Approximately 10% of melanoma cases report a relative affected with melanoma, and a positive family history is associated with an increased risk of developing melanoma. Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of heritable melanoma risk genes is an important component of disease occurrence. Susceptibility for some fam...

BACKGROUND Little information exists on the epidemiology of melanoma and the role of solar radiation in the development of melanoma in pigmented populations. OBJECTIVE To evaluate the relationship between exposure to solar radiation and the incidence of melanoma in US Hispanics and blacks. DESIGN Population-based ecological study. SETTING State cancer registries of New York, New Jersey, I...

Skin is a vital component of the human body and covers the entire human system. Skin cancer is one of the complex and severe types of cancer. Nowadays young adults are mostly affected by skin cancer. In spite of the unforeseen progression medical science, curing skin cancer is a complex process. Malignant melanoma is one type of skin cancer, which cannot be cured and leads to death unless detec...

Skin cancer is the deadliest form of cancers in humans. Skin cancer is commonly known as Melanoma. Melanoma is named after the cell from which it presumably arises, the melanocyte. Skin Cancers are of two typesBenign and Malignant Melanoma. Melanoma can be cured completely if it is detected early. Both benign and malignant melanoma resembles similar in appearance at the initial stages. So it is...

The incidence of melanoma has been increasing at an alarming rate worldwide. Although melanoma accounts for only 10% of skin cancer, it is responsible for at least 80% of skin cancer deaths. Malignant melanoma remains one of the cancers most resistant to treatment. Moreover, no effective therapy exists to inhibit the metastatic spread of this type of cancer. Research to further understanding of...

INTRODUCTION Melanoma, a cancer originating in melanocytes, is the most deadly form of skin cancer and the sixth leading type of cancer in the U.S.1 According to the World Health Organization, approximately 53,000 people die of melanoma each year worldwide.2 In 2011, an estimated 70,230 adults were diagnosed with melanoma in the U.S., and 8,790 died of the disease.3,4 This may be an underestima...

BACKGROUND Based on the hypothesis that ultraviolet radiation (UVR) exposure can cause DNA damage that may activate dormant viruses such as human papilloma virus, a recent ecological study, which estimated state-level UVR exposure, reported positive correlations between annual UVR exposure and the incidence of oral, pharyngeal, and cervical cancer in 16 U.S. states using the International Agenc...

BACKGROUND Skin cancer is the most common cancer in the United States. Increasing evidence suggests that screening for malignant melanoma is effective, but its cost-effectiveness has not been determined. OBJECTIVE We attempted to determine the effectiveness and costs of a visual screen to diagnose malignant melanoma in high-risk persons. METHODS We developed a decision analysis comparing no...

Melanoma, the most aggressive form of skin cancer, has increased in incidence more rapidly than any other cancer. The completion of the human genome project and advancements in genomics technologies has allowed us to investigate genetic alterations of melanoma at a scale and depth that is unprecedented. Here, we survey the history of the different approaches taken to understand the genomics of ...