9510 Background: Survivors of childhood cancer are at increased risk of developing subsequent neoplasms. The incidence and clinical characteristics of subsequent melanoma has not been well described in survivors of childhood cancer. METHODS Analysis included 14,358 5-year survivors of childhood cancer diagnosed between 1970-1986. Cumulative incidence (CIN) of first occurrence of subsequent me...

The continuous rise in skin cancer cases, especially malignant melanoma, has resulted a high mortality rate of the affected patients due to late detection. Some challenges affecting success detection include small datasets or data scarcity problem, noisy data, imbalanced inconsistency image sizes and resolutions, unavailability reliability labeled (ground truth), imbalance datasets. This study ...

Cancer cells have unique nanomechanical properties, i.e., they behave as if they were elastic. This property of cancer cells is believed to be one of the main reasons for their facilitated ability to spread and metastasize. Thus, the so-called nanomechanical phenotype of cancer cells is viewed as an important indicator of the cells' metastatic behavior. One of the most highly metastatic cancer ...

Melanoma is the most dangerous and treatment-resistant skin cancer. Tumor resistance and recurrence are due to the persistence in the patient of aggressive cells with stem cell features, the cancer stem cells (CSC). Recent evidences have shown that CSC display a distinct metabolic profile as compared to tumor bulk population: a promising anti-tumor strategy is therefore to target specific metab...

Objective(s): Despite recent advances in treatment modalities, cancer remains a major source of morbidity and mortality throughout the world. Currently, the development of sensitive and specific molecular imaging probes for early diagnosis of cancer is still a problematic challenge. Previous studies have been shown that some of the antimicrobial peptides (AMPs) exhibit...

 SUMMARY X. Pis a rare autosomal recessive genodermatosis characteriseJ by photophohia, severe solar sensitivity, cutaneous pigmentary changes, xerosis and early Jevdopment of mucocutaneous and ocular cancer particularly in sun exposeJ skin. Tumors whichinclude solar keratosis, cutaneous horn, keratoachanthoma, squamous and basal cell carcinoma, malignant melanoma and angioma may developeJ in...

With skin cancer incidence rate steadily increasing each year, melanoma continues to pose a significant public health problem globally. It is well-known that early detection and prevention of remains the most important intervention for reducing morbidity mortality, therefore it imperative promote innovation will advance our ability diagnose early. Because prognosis treatment are dependent on de...

Malignant melanoma originates from melanocytes, pigment-producing cells of neural crest origin that acquire the ability to invade and metastasize. While melanoma represents one of the rarer forms of skin cancer, it is responsible for the majority of skin-cancer-related deaths. The overall incidence of melanoma has increased significantly in the past decades and the incidence of melanoma is high...

BACKGROUND: Deevelopment of new diagnostics and treatment malignant neoplasms methods increase their efficiency, safety is one the most urgent tasks modern oncology. Currently, targeted immunotherapy contributes to neoplasms. One examples skin melanoma.
 AIMS: This study aimed investigate influence therapeutic tactics on epidemiological indicators in morbidity MATERIALS AND METHODS: The us...

The UDP-glucuronosyltransferase (UGT) family of enzymes plays a vital role in the detoxification of carcinogens as well as clearance of anti-cancer drugs. In humans, 19 UGT family members have been identified and are expressed in a tissue specific manner throughout the body. However, the UGTs have not been previously characterized in melanocytes or melanoma. In the present study, UGT2B7, UGT2B1...