= Abstract =MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode) is a rare and currently incompletely defined mitochondrial disease involving mainly muscle and brain. We have recently seen a 17-year-old male patient who, we believe, is the first Korean case. The patient showed the classical picture of MELAS: short stature, generalized limb weakness, ...

Introduction Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by We...

In a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS), both T2- and diffusion-weighted MR imaging revealed lesions as hyperintense areas in the occipital lobes early after strokelike episodes. In these lesions, no significant reduction in apparent diffusion coefficient was noted. Apparent diffusion coefficient mapping may help to differentiat...

Invasive infection with the opportunistic fungus Aspergillus fumigatus predominantly affects people with impaired cell mediated immunity. The case of a 31 year old woman with no identified cause for immunosuppression who presented with severe refractory aspergillosis of the paranasal sinuses is reported. She subsequently developed clinical and molecular evidence of mitochondrial encephalomyopat...

A 48-year-old man was admitted for workup of stroke-like symptoms and generalised tonic-clonic seizures. History and examination revealed that the patient had background diagnoses of type 2 diabetes mellitus, epilepsy and had suffered a temporal lobe infarct 3 years ago. The unusual presentation and physical findings, along with subsequent MRI findings led to a diagnosis of mitochondrial myopat...

Bu çalışmada, şeker pancarı melasından fermantasyonla biyoetanol üretimi incelenmiştir. amaçla, iki aşamalı deneysel çalışma gerçekleştirilmiştir: Melasın enzimatik hidrolizi ile basit şekerlerin üretilmesi ve hidrolizattan E.coli KO11 üretilmesi. Enzimatik hidroliz deney parametreleri (melas konsantrasyonu, enzim konsantrasyonu süre) cevap yüzey metodu (RSM) optimize edilmiştir. Cevap değişken...

With interest we read the article by Dvorakova et al. about 50 Czech patients carrying the m.3243ANG mutation [1]. It raises questions and concerns. Since MELAS is a progressive disease, we should be informed about the long-term follow-up findings in the 50 mutation carriers. How many of the 17 patients without clinical manifestations at inclusion developed MELAS during follow-up? How many of t...