Background and aim: Melissa officinalis was traditionally used for pain relief and treatment of some diseases. The aim of the study was to compare the effect of mefenamic acid and Melissa officinalis (Melissa) on pain management in primary dysmenorrhea. Methods: In this clinical trial, fortythree eligible women with moderate to severe primary dysmenorrhea were randomly allocated into the Meliss...

BACKGROUND Melissa officinalis, an herbal drug, is well known and frequently applied in traditional and modern medicine. Yet, there is inadequate information regarding its effects on electrical properties of the heart. The present study attempted to elucidate the effects of Melissa officinalis aqueous extract on electrocardiogram (ECG) in rat. OBJECTIVES ECG is an easy, fast and valuable tool...

Malathion (ML) is a well known pesticide commonly used in many agricultural and non-agricultural processes. Its toxicity has been attributed primarily to the accumulation of acetylcholine (Ach) at nerve junctions, due to the inhibition of acetylcholinesterase (AChE). The aim of the current research was to study the protective effect of the melissa plant extract against reproductive impairment i...

Melissa officinalis, Labiateae has been used for the treatment of several disorders including diseases of the heart, liver, brain, insanity, giddiness, gripping, muscular pain, asthma, hydrophobia, tuberculous glands, headache, and scabies. In the present study immunomodulatory property of isolated compound obtained from ethanolic extract of whole plant of Melissa officinalis was investigated. ...

OBJECTIVE To assess the efficacy and safety of Melissa officinalis extract using a fixed dose (60 drops/day) in patients with mild to moderate Alzheimer's disease. DESIGN A four month, parallel group, placebo controlled trial undertaken in three centres in Tehran, Iran. METHODS Patients with mild to moderate Alzheimer's disease aged between 65 and 80 years (n = 42; 18 women, 24 men) with a ...