نتایج جستجو برای: memory, p53, Resveratrol

تعداد نتایج: 308106  

Objective(s): Both caloric restriction (CR) and resveratrol (RSV) have been shown to improve learning and memory, but their potential effects in juvenile animals were unknown. Here, we evaluated the effects of RSV and CR on learning and memory function in juvenile mice and investigated potential molecular mechanisms. Methods: Six-week-old C57BL/6J mice were assigned to one of three different d...

Journal: :Cancer research 2001
Q B She A M Bode W Y Ma N Y Chen Z Dong

Resveratrol, a phytoalexin found in grapes, berries, and peanuts, is one of the most promising agents for cancer prevention. Our previous study showed that the antitumor activity of resveratrol occurs through p53-mediated apoptosis. In this study, we have elucidated the potential signaling components underlying resveratrol-induced p53 activation and induction of apoptosis. We found that in a mo...

2015
Yu-Tang Chin Sheng-Huei Yang Tung-Cheng Chang Chun A. Changou Hsuan-Yu Lai Earl Fu Wei-Chun HuangFu Paul J. Davis Hung-Yun Lin Leroy F. Liu

Dihydrotestosterone (DHT) has been shown to promote breast cancer growth via different mechanisms. In addition to binding to ERα, the DHT membrane receptor exists on integrin αvβ3. Resveratrol induces p53-dependent apoptosis via plasma membrane integrin αvβ3. Resveratrol and DHT signals are both transduced by activated ERK1/2; however, DHT promotes cell proliferation in cancer cells, whereas re...

2012
Danielly Cristiny Ferraz da Costa Fabiana Alves Casanova Julia Quarti Maitê Santos Malheiros Daniel Sanches Patricia Souza dos Santos Eliane Fialho Jerson L. Silva

Resveratrol is a promising chemopreventive agent that mediates many cellular targets involved in cancer signaling pathways. p53 has been suggested to play a role in the anticancer properties of resveratrol. We investigated resveratrol-induced cytotoxicity in H1299 cells, which are non-small lung cancer cells that have a partial deletion of the gene that encodes the p53 protein. The results for ...

Journal: :Molecular cancer therapeutics 2004
Ai Shih Shenli Zhang H James Cao Sarah Boswell Yun-Hsuan Wu Heng-Yuan Tang Michelle R Lennartz Faith B Davis Paul J Davis Hung-Yun Lin

Resveratrol, a naturally occurring stilbene with antitumor properties, caused mitogen-activated protein kinase [MAPK, extracellular signal-regulated kinase 1/2 (ERK1/2)] activation, nuclear translocation of Ser15-phosphorylated p53, and p53-dependent apoptosis in hormone-insensitive DU145 prostate cancer cells. Exposure of these cells to epidermal growth factor (EGF) for up to 4 hours resulted ...

2016
Bhaswati Banerjee Supriya Chakraborty Debidas Ghosh Sanghamitra Raha Parimal C. Sen Kuladip Jana

Benzo(a)pyrene (B(a)P) is an environmental toxicant that induces male germ cell apoptosis. Curcumin and resveratrol are phytochemicals with cytoprotective and anti-oxidative properties. At the same time resveratrol is also a natural Aryl hydrocarbon Receptor (AhR) antagonist. Our present study in isolated testicular germ cell population from adult male Wistar rats, highlighted the synergistic p...

2015
ZHIBING AI CHENGYAN LI LONGTI LI GUOHOU HE

The natural product resveratrol possesses diverse biological activities, including anti‑inflammatory, anti‑oxidant, anti‑cancer and anti‑aging effects in multiple organisms. The neuroprotective role of resveratrol has recently been reported in a cell model of amyloid (A)β(25‑35)‑induced neurotoxic injury using PC12 cells. However, the pathomechanism by which resveratrol inhibits neuronal apopto...

Journal: :Phytotherapy Research 2021

The present study sought to evaluate the effect of resveratrol supplementation on mRNA expression levels peroxisome proliferator-activated receptor alpha (PPARα), p53, p21, p16, and serum cluster differentiation 163 (CD163) TNF-like weak inducer apoptosis (TWEAK) ratio in patients with type 2 diabetes. In this double-blind randomized controlled trial, 71 were randomly assigned receive either 1,...

2004
Ai Shih Shenli Zhang H. James Cao Sarah Boswell Yun-Hsuan Wu Heng-Yuan Tang Michelle R. Lennartz Faith B. Davis Paul J. Davis Hung-Yun Lin

Resveratrol, a naturally occurring stilbene with antitumor properties, caused mitogen-activated protein kinase [MAPK, extracellular signal-regulated kinase 1/2 (ERK1/2)] activation, nuclear translocation of Ser-phosphorylated p53, and p53-dependent apoptosis in hormone-insensitive DU145 prostate cancer cells. Exposure of these cells to epidermal growth factor (EGF) for up to 4 hours resulted in...

Journal: :Mutation research 2003
Zigang Dong

Chemoprevention is a promising approach to control human cancer. Resveratrol has been shown to have a potent chemopreventive effect in multiple carcinogenesis models. However, the precise mechanism explaining its anti-carcinogenic effect is not clear. This review summarizes recent studies from our laboratory on the mechanisms of resveratrol's effects. In JB6 cells, resveratrol was found to indu...

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