neuroinflammation has a significant role in induce of multiple sclerosis (ms) many approaches have been used to treat ms, but none of these methods have not been able to fully improve. one of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuro...

In situ analysis of fetal semilunar valve leaflets has revealed cells coexpressing endothelial and mesenchymal markers along the endothelium, with diminished frequency seen in adult valves. To determine whether such cells are progenitor cells, we isolated clonal populations from human pulmonary valves. The clones expressed endothelial markers but showed potential to further differentiate into e...

Stem cell research and the prospect of stem cell based therapies depend critically on the identification of specific markers that can be used for the identification and selection of stem and progenitor cells. Nestin is expressed in neuronal progenitor cells and has also been suggested to mark multipotent pancreatic stem cells. We show here that, throughout pancreatic development, markers of pan...

Studies on hematopoiesis have focused on the function and composition of human bone marrow stroma. Stroma function gives hematopoietic stem cells the microenvironment appropriate for self-renewal and/or prompt differentiation into hematopoietic progenitor cells, then into terminal specialized cells. Human bone marrow stroma has been dissected into hematopoietic and nonhematopoietic components. ...

objective: cardiac cell differentiation with the help of mirnas has recently opened a promising window for the restoration of myocardial infarction. independent mir-1-2/133a-1 and mir-206/133b clusters are known to be expressed in cardiac and skeletal muscles, respectively. mir-133b differs from mir-133a by only one nucleotide. the sequence similarity of these two mirnas suggests that they targ...

Thymic epithelial cells, which create a three-dimensionally organized meshwork structure peculiar to the thymus, develop from simple epithelia of the third pharyngeal pouch and cleft during organogenesis. We comparatively investigated the thymus anlages of normal and nude mice by immunohistochemical analysis with regard to epithelial organization and distribution of hematopoietic progenitor cel...

background: the definitive endoderm (de) differentiation using the undefined media and non-human feeders can cause contaminations in the generated cells for therapeutic applications. therefore, generating safer and more appropriate de cells is needed. this study compared five different methods to establish an appropriate method for inducing an efficient de differentiation from human induced plu...

background: recent publications about differentiation of stem cells to germ cells have motivated researchers to make new approaches to infertility. in vitro production of germ cells improves understanding differentiation process of male and female germ cells. due to the problem of using embryonic stem cells (esc), it’s necessary the mentioned cells be replaced with some adult multi-potent stem ...

background: mesenchymal stem cells (mscs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. however, the low survival rate of these cells restricts their therapeutic applications. it is hypothesized that autophagy might play an important role in cellular homeostasis and survival. this study aims to investigate the regenerative potentia...

background: wound healing of burned skin remains a major goal in public health. previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds. methods: in this study, mesenchymal stem cells were derived from rat adipose tissues and characterized by flowcytometry. staining methods were used to evaluate their differentiatio...