recent findings in stem cell biology have opened a new window in regenerative medicine. the endometrium possesses mesenchymal stem cells (mscs) called endometrial stem cells (enscs) having specific regenerative properties linked to adult stem cells. they contribute in tissue remodeling and engineering and were shown to have immuno-modulating effects. many clinical trials were undertaken to asce...

  Introduction: The field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice. Stem cell therapy seems to be a new treatment option for some diseases. So, tracking the distribution of stem cells is crucial to their therapeutic use. Based on this fact we labeled human mesenchymal stem cells (MSCs) with 111...

the complexity of multiple sclerosis (ms) and the incompetence of a large number of promise treatments in ms urge us to plan new and more effective therapeutic approaches that aim to suppress ongoing autoimmune responses and induction of local endogenous regeneration. emerging data propose that hematopoietic, mesenchymal and neural stem cells have the potential to restore self-tolerance, to pro...

Background Chronic allograft nephropathy(CAN)  is one of the most common causes of chronic and end stage renal disease. It  is defined with Mainly tubular atrophy and  interstitial fibrosis and no evidence of any other etiology, or functional disorder that caused at least three months after transplantation . Control of risk factors (HTN,DM,HLP, …) and limiting  usage of calcineurin inhibitors...

Objective(s) The use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (MSC) bone differentiation in culture. In this regard, there is no study considering the effects of Matrigel on mesenchymal stem cell (MSC) in vitro bone differentiation. This was the subject of the present study. Materials and Methods ...

Mesenchymal Stem Cell-Hybrid Nanovehicles In article 2300376, Donghang Xu, Tianyuan Zhang, Jianqing Gao and co-workers develop a biomimetic nanovehicle hybridizing the cell membrane of mesenchymal stem with liposome. This hybrid shows advantages both highly efficient inflammation targeting good drug-loading capacity, resulting in specifically targeted delivery methylprednisolone to inflammatory...

Neurodegenerative diseases are the hereditary and sporadic diseases which are characterized by progressive neuronal loss of the nervous system and are emerging as the leading cause of death, disabilities, and a socioeconomic burden due to an increase in life expectancy. There are many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s, disease, amyotrophic lateral...

how to cite this article: : farivar s, mohamadzade z, shiari r, fahimzad ar. neural differentiation of human umbilical cord mesenchymal stem cells by cerebrospinal fluid. . iran j child neurol. 2015 winter; 9(1):87-93.     abstract objective wharton’s jelly (wj) is the gelatinous connective tissue from the umbilical cord. it is composed of mesenchymal stem cells, collagen fibers, and proteoglyc...

Background: In this study, we examined a new two step induction protocol for improving the differentiation of human umbilical cord blood-derived mesenchymal stem cells into neural progenitor cells. Materials and Methods: Human umbilical cord blood-derived mesenchymal stem cells were first cultured in Dulbecco’s modified eagle medium supplemented with 10% fetal bovine serum in a humidified incu...