Spider venoms are complex cocktails rich in peptides, proteins and organic molecules that collectively act to immobilize prey. Venoms of the primitive hunting spider, Plectreurys tristis, have numerous neurotoxic peptides called "plectoxins" (PLTX), a unique acylpolyamine called bis(agmatine)oxalamide, and larger unidentified protein components. These spiders also have unconventional multi-lobe...

Role of 2-Deoxy-D-glucose (2-DG) in reversing the Indian red scorpion (Mesobuthus tamulus concanesis Pocock, MBT) venom-induced toxicity was examined. Femoral arterial pressure, ECG and respiratory movements were recorded in urethane anesthetized rats. Plasma glucose and serum insulin levels were also estimated. Intravenous injection of 5 mg/kg MBT venom produced immediate decrease in mean arte...

Scorpion bite is common in rural areas of India with self limiting local reaction and pain at envenomation site, however envenomation due to Mesobuthus tamlus (Indian red scorpion) some time have uncommon systemic manifestation like myocarditis, pulmonary edema, pancreatitis, defibrination syndrome, DIC and CNS manifestation due to hemorrhagic infarct, all these systemic manifestation is corrob...

Animal venoms are a mixture of peptides and proteins that serve two basic biological functions: predation and defense against both predators and microbes. Antimicrobial peptides (AMPs) are a common component extensively present in various scorpion venoms (herein abbreviated as svAMPs). However, their roles in predation and defense against predators and potential as drugs are poorly understood. ...

UNLABELLED The scorpion Mesobuthus martensii is the most populous species in eastern Asian countries, and several toxic components have been identified from their venoms. Nevertheless, a complete proteomic profile of the venom of M. martensii is still not available. In this study, the venom of M. martensii was analyzed by comprehensive proteomic approaches. 153 fractions were isolated from the ...

In the neurotomised animals, venom-induced mean arterial pressure (MAP) and respiratory rate (RR) changes were markedly attenuated but not the heart rate (HR) changes indicating the existence of additional afferent pathway. Hence, further sets of experiments were performed to explore the afferents. Albino rats were anaesthetised with an intra-peritoneal injection of urethane (1.5 g/kg). Tracheo...