The gestational period is marked by an intense anabolic process. Weeks after conception, the placenta already formed and begins to secrete important hormones related metabolism of various nutrients. These alter maternal metabolism, promote fetal growth, prepare mother for labor lactation (HARREITER J. et al.,2006).

backgrounds and aims: thyroid hormones have a crucial physiological role to maintain balance of metabolism of body. thyroid hormones have an important role in metabolism and proliferation of blood cells. thyroid gland also has a vital influence on erythropoiesis by induction of erythropoietin secretion and proliferation of erythroid progenitors. in the present study, it was tried to evaluate th...

The role of DNA methylation in cardiomyocyte physiology and cardiac disease remains a matter controversy. We have recently provided evidence for an important DNMT3A human cell homeostasis metabolism, using engineered heart tissue (EHT) generated from induced pluripotent stem (hiPSC)-derived cardiomyocytes carrying knockout the de novo methyltransferase DNMT3A. Unlike isogenic control EHT, EHT d...

Background: Ornithine (Orn) plays an essential role in the metabolism of plant cells through incorporation in polyamines biosynthesis, the urea cycle and nitrogen metabolism. Physiological response of the plant cells to its two enantiomers have not been widely investigated yet.Objectives: This study aimed to evaluate effect of ornithine enantiomers on exp...

Objective(s): Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. Material and Methods:Metabolism of c...

The zinc metalloprotease, neprilysin (NEP), plays a role in the metabolism of cardiovascular, inflammatory and neuropeptides, including mitogenic peptides such as bombesin. In the cardiovascular system, NEP has a primary role in the inactivation of natriuretic peptides but also contributes to local metabolism of angiotensin, endothelins and bradykinin. Hence NEP is seen as a potential therapeut...

Epithelial Ovarian cancer is the leading cause of cancer mortality among women all over the world. As chemotherapeutics has many side effects, researchers have focused on the potential use of medicinal plants as natural antitumor agents. Xanthium strumarium studied in this work as an herbal anticancer agent. This study aimed to evaluate the antitumor effect and metabolic alterations ca...

Background and objectivesMethylenetetrahydrofolate Reductase (MTHFR) is the critical enzyme in folate 1-carbon metabolism. MTHFR polymorphisms may result increased homocysteine levels, be associated with abnormal lipid metabolism liver. This study aims to explore association between gene of rs1801131 rs1801133 susceptibility nonalcoholic fatty liver disease (NAFLD) coronary artery (CAD).