A new hydroxylated metabolite of tamoxifen, Metabolite Y [trans-1-(p-beta-hydroxyethoxyphenyl)-1,2-diphenylbut-1-ene] was characterized and subsequently measured by high-performance liquid chromatography in serum from patients receiving normal (10 mg twice daily) and high dose (greater than or equal to 150 mg twice daily) tamoxifen therapy for treatment of advanced breast cancer. In normal-dose...

eight wheat varieties some of which were earlier reported to be resistant to pythium arrhennmanes, were inoculated with p. arrhenomanes. inoculation was performed by placing 2-day-old seedlings on the edge of a p. arrhenomanes culture on corn meal agar for 3 h at 25°c. infected seedlings were then transferred to test tubes (9 mm dia.) containing glass beads and 1 ml of sterile water, and in...

Dissociated agonists of the glucocorticoid receptor (DAGRs) show similar antiinflammatory effects but improved tolerability compared with standard glucocorticoid receptor (GR) agonists. The prodrug fosdagrocorat (PF-04171327), with active DAGR metabolite PF-00251802 (Metabolite-1), is postulated to show superior efficacy over placebo and prednisone in patients with moderate to severe rheumatoid...

abstract background: increase in nitric oxide (no) concentration accompanied by alteration in peritoneal immune defense reactions is involved in the pathogenesis of endometriosis. asymmetric dimethylarginine is an endogenous competitive inhibitor of no synthase. this study was designed to compare no metabolite (nitrite), asymmetric dimethylarginine, and estradiol concentrations in serum and per...

In the present study, models were developed to estimate the altitudinal variation in secondary metabolite contents of Hypericum orientale growing wild in “Güldağı” mountain, Turkey. Aerial parts of flowering 30 individuals were collected at six different altitudes (500, 1150, 1650, 2100, 2720 and 3250 m). Actual secondary metabolite contents of plants were measured by High Performance Liquid Ch...

The role of hepatic intrinsic clearance for metabolite formation from various precursors on subsequent metabolite elimination was was investigated in the once-through perfused rat liver preparation. Two pairs of acetaminophen precursors: [14C] phenacetin-d5 and [3H] phenacetin-do, [14C] acetanilide and [3H] phenacetin were delivered by constant flow (10 ml/min/liver) either by normal or retrogr...