نتایج جستجو برای: methoxy poly(ethylene glycol)

تعداد نتایج: 50452  

2010
Fernando Carrera Charmaine E. Lok Angel de Francisco Francesco Locatelli Johannes F.E. Mann Bernard Canaud Peter G. Kerr Iain C. Macdougall Anatole Besarab Giuseppe Villa Isabelle Kazes Bruno Van Vlem Shivinder Jolly Ulrich Beyer Frank C. Dougherty

BACKGROUND Several studies with erythropoiesis-stimulating agents claim that maintenance therapy of renal anaemia may be possible at extended dosing intervals; however, few studies were randomized, results varied, and comparisons between agents were absent. We report results of a multi-national, randomized, prospective trial comparing haemoglobin maintenance with methoxy polyethylene glycol-epo...

Journal: :iranian journal of biotechnology 2014
zahra gholami sameereh hashemi najafabadi masoud soleimani

background: host immune system response against blood group antigens is a major problem in blood transfusions, especially forthalassemic patients. thus, an approach was proposed coating the red blood cell (rbc) surface by polyethylene glycol.objectives: this study aimed to obtain the optimal simultaneous camouflge of the major and minor antigens by activated methoxypolyethylene glycol (mpeg) wi...

Journal: :علوم و تکنولوژی پلیمر 0
سمیره هاشمی نجف آبادی ابراهیم واشقانی فراهانی عباس شجاع الساداتی یاسوهیرو ایواناگا

the final treatment for diabetes is transplantation of islets of langerhans. one of the new proposed methods for immunological preservation of transplanted cells is coating of cell surface by polyethylene glycol. in this study, the surface of islets of langerhans was coated by cyanuric chloride activated methoxy polyethylene glycol. the effect of polymer coating, at two different reaction times...

Journal: :علوم و تکنولوژی پلیمر 0
سمیره هاشمی نجف آبادی ابراهیم واشقانی فراهانی سید عباس شجاع الساداتی محمدجواد رسایی

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Journal: :Chemical communications 2013
Haihua Xiao Jared F Stefanick Xiaoyu Jia Xiabin Jing Tanyel Kiziltepe Yu Zhang Basar Bilgicer

Nanoparticles formed via electrostatic interactions between methoxy-polyethylene glycol-block-poly(glutamic acid) (MPEG-PGA) and a multinuclear platinum(II) drug, di-cisPt, exhibit efficient platinum loading, improved cellular uptake, in vitro cytotoxicity, and enhanced in vivo efficacy.

Journal: :FEBS letters 1994
S Zalipsky E Brandeis M S Newman M C Woodle

Ligand attachment to polyethylene glycol (PEG) grafted, long circulating liposomes at the polymer terminus is of interest for targeting but the effect of positively charged groups is unknown. Amino-polyethylene glycol-phosphatidylethanolamine (AminoPEG-PE), prepared in four steps from alpha-amino-omega-hydroxy-PEG, was tested for influence on liposome interactions in vivo: blood circulation and...

Journal: :modares journal of medical sciences: pathobiology 2015
shahin haghdoost sameereh hashemi-najafabadi masoud soleimani

objective: because of the host immunological system response against the minor blood groups of donor, transfusion in some cases, especially for patients require repeated transfusions (such as people with thalassemia), can be considered as a significant problem.  a proposed way is coating the surface antigens on red blood cells (rbcs) by covalent binding of methoxy polyethylene glycol (mpeg). th...

Journal: :The Journal of pharmacology and experimental therapeutics 2002
Wai Ming Li Lawrence D Mayer Marcel B Bally

One of the major obstacles in the development of ligand-targeted liposomes is poor liposome circulation longevity as a result of antibody-mediated elimination of these highly immunogenic carriers. Because studies from our laboratory suggest that it is not possible to reduce the immunogenicity of ligand-conjugated liposomes by using surface-grafted poly(ethylene glycol) (PEG), we investigated th...

2014
Guanghua Liu Jianqun Gan Aimin Chen Qian Liu Xusheng Zhao

An amphiphilic N-octyl-O-methoxy poly (ethylene glycol) chitosan was successfully prepared by grafting successively octyl groups onto amino groups at chitosan’s C-2 position as hydrophobic moieties and methoxy polyethylene glycol (MPEG) groups onto hydroxyl groups at C-6, C-3 as hydrophilic ones. A certain amount of -NH2 was retained in the structure of chitosan derivatives through protection b...

Journal: :Bioengineering & translational medicine 2023

Multiple studies have shown that the progression of breast cancer depends on multiple signaling pathways, suggesting therapies with multitargeted anticancer agents will offer improved therapeutic benefits through synergistic effects in inhibiting growth. Dual-targeted inhibitors phosphoinositide 3-kinase (PI3-K) and histone deacetylase (HDAC) emerged as promising therapy candidates. However, po...

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