Viral vectors represent an attractive technology for vaccine delivery. We exploited the integrase defective lentiviral vector (IDLV) as a platform for delivering relevant antigens within the context of the ADITEC collaborative research program. In particular, Influenza virus hemagglutinin (HA) and nucleoprotein (NP) were delivered by IDLVs while H1N1 A/California/7/2009 subunit vaccine (HAp) wi...

Trivalent influenza virus A/Duck/Singapore (H5N3), A/Panama (H3N2), and B/Guandong vaccine preparations were used in a randomized, controlled, dose-ranging phase I study. The vaccines were prepared from highly purified hemagglutinin and neuraminidase from influenza viruses propagated in embryonated chicken eggs and inactivated with formaldehyde. We assigned 100 participants to six vaccine group...

BACKGROUND: Vaccination is the most effective way to prevent influenza and its complications. The MF59-adjuvanted quadrivalent (aQIV) high-dose (QIV-HD) vaccines have been specifically developed protect subjects aged ≥65 years. aim of this study was evaluate economic consequences associated with use aQIV in elderly population Italy.METHODS: An Excel-based budget impact model estimate costs for ...

Many viral infections, including HIV, exhibit sex-based pathogenic differences. However, few studies have examined vaccine-related sex differences. We compared immunogenicity and protective efficacy of monomeric SIV gp120 with oligomeric SIV gp140 in a pre-clinical rhesus macaque study and explored a subsequent sex bias in vaccine outcome. Each immunization group (16 females, 8 males) was prime...

Abstract H5N1 vaccines adjuvanted in the oil-in-water emulsion MF59 are maintained Strategic National Stockpile for pre-pandemic preparedness. The US population currently naïve to H5 and a prime/boost regimen will likely be needed engender protective response. Ideally, rapid response pandemic influenza would benefit from being able induce protection single dose of vaccine. Here, we have used sy...