BACKGROUND Neoplasia results from various genetic and epigenetic factors. Our study focused on the pathogenesis which involved an imbalance in various molecular mechanisms which regulated cell proliferation and apoptosis. The anti-apoptotic mechanism is regulated by Bcl-2 gene, while Ki-67 is expressed exclusively in nuclei of proliferating cells. This study was done to evaluate the basic patho...

In order to evaluate the potential risk factors for Lymph node metastasis in invasive breast cancer patients submitted to axillary dissection, 675 patients who received surgery between January 1995 and December 2002 were included in a prospective study. In all cases, MIB-1 proliferation index was investigated by immunohistochemistry. Lymph node involvement was found in 248 out of 675 patients. ...

We observed a co-upregulation of the insulin-like growth factor receptor (IGF-1R)/AKT/mammalian target of rapamycin (mTOR) [InAT] axis and the mevalonate-isoprenoid biosynthesis (MIB) pathways in colorectal cancer stem cells (CSCs) in an unbiased approach. Hence, we hypothesized that the InAT axis might regulate the MIB pathway to govern colorectal CSCs growth. Stimulation (IGF-1) or inhibition...

BACKGROUND Notch signaling is an evolutionarily conserved developmental pathway. Zebrafish mind bomb (mib) mutants carry mutations on mib gene, which encodes a RING E3 ligase required for Notch activation via Delta/Jagged ubiquitylation and internalization. METHODOLOGY/PRINCIPAL FINDINGS We examined the mib mutants for defects in pancreas development using in situ hybridization and GFP expres...

With this study, we aimed to determine (1) the effect of daily new cases and deaths due COVID-19 pandemic in United States on CBOE volatility index (VIX index) (2) VIX major stock markets during early stage period. To do this, collected analysed death numbers period country indexes USA (DJI), Germany (DAX), France (CAC40), England (FTSE100), Italy (MIB), China (SSEC) Japan (Nikkei225) impact ma...

As taste-and-odor outbreaks are common in surface waters worldwide, extensive studies have focused on the identification of microorganisms involved production 2-methylisoborneol (MIB) and geosmin (GSM). However, fewer tried to identify potential degraders natural environments. Eagle Creek Reservoir, a temperate eutrophic water body, experienced two major seasonal odorous 2013 with maximal conce...

This memo defines a portion of the Management Information Base (MIB) for use with network management protocols in TCP/IP-based internets. In particular, it defines objects for managing a client using the Internet Small Computer System Interface (iSCSI) protocol (SCSI over TCP). Bakke, et al. Standards Track [Page 1] RFC 4544 iSCSI MIB May 2006