background and objective: n-methyl-d-aspartate (nmda) antagonists such as piperidines are the most important antiepileptic drugs. considering the fact that piperidine derivatives such as phencyclidine (pcp) and its new derivative, 1-[1-(3-methoxyphenyl) (tetralyl)] piperidine (pcp1), have different potencies, the antiepileptic effects of mentioned drugs were investigated in the present study. ...

in the present study the effects of both cck receptor agonists and antagonists on antinociception induced by morphine in the tail-flick test have been evaluated. m orphine induced dose-dependent antinociception in mice. the response of morphine was potentiated by sulfated cholecystokinin-8 (cck-8s) but not by unsulfated cholecystokinin-8 (cck-8u). the cck receptor antagonists mk-329 and l-365, ...

introduction: there is not much data on parasitic infections of laboratory animals that are kept in conventional conditions in iran. the present study was designed to investigate intestinal helminths infections in laboratory colonies of rats and mice. methods: droppings from 110 mice and 110 rats (each animal one dropping) belonging to experimental and breeding groups in four animal houses were...

background and objective: regarding inefficiency of common drugs used for alleviation of anxiety due to narcotics withdrawal, the present study was evaluated methadone and haloperidol co-drugs therapy on anxiety due to morphine withdrawal. materials and methods: ninety eight nmri male mice were divided into acute and chronic experimental groups. then, each group was divided into 7 subgroups: sa...

background: successful embryo transfer (et) technique is a fateful step of all efforts to achieve live births from in vitro produced embryos in assisted reproductive techniques or in knockout, transgenic or cloned animal projects. small reproductive tract of mice and limitation of current techniques may not well satisfy the requirements for mass production of genetically modified mice. genetic ...

background: there are few studies indicating the detrimental effects of ibuprofen on sperm fertility potential and dna integrity. objective: to determine the effects of ibuprofen on sperm parameters, chromatin condensation and dna integrity of mice. materials and methods: in this experimental study, 36 adult male mice with average weight 37 gr were divided into three groups, including control (...

background: lippia citriodora kunth is one of the iranian traditional medicines for the treatment of convulsive disorders. the goal of this study is to investigate the anticonvulsant activity of the plant’s leave ethanolic extract against electro‑ and chemoconvulsant‑induced seizures in mice. methods: the anticonvulsant activity of the extract (200, 400, 800 mg/kg, per os, p.o.) was investigate...

bile duct ligation (bdl) is shown to induce cholestasis-related liver function impairments as well as consequent cognitive dysfunctions (i.e. impaired learning and memory formation). this study investigates the effects of cholestasis (14, 21 and 28 days post bile duct ligation) on spatial and non-spatial novelty detection, using a non-associative task. male mice weighing 30-35 g were used. chol...

background cyclophosphamide (cp) is one of the most popular alkylating anticancer drugs despite its toxic side effects, including nephrotoxicity, hematotoxicity, mutagenicity, and immunotoxicity. capparis spinosa is a multipurpose plant that contains a number of chemically active and diverse secondary metabolites, particularly flavonoids. rutin and quercetin are two major flavonoids in the cape...

background: pyridaben, a pyridazinone derivative, is a new acaricide and insecticide for control of mites and some insects such as white flies, aphids and thrips. objective: this study was designed to elucidate how pyridaben can affect the sperms' morphological parameters, its dna integrity, and to estimate the effect of various quantities of pyridaben on in vitro fertilization rate. materials ...