Reductionism assumes that causation in the physical world occurs at the micro level, excluding the emergence of macro-level causation. We challenge this reductionist assumption by demonstrating that, once causal power is properly defined and measured, it is possible for a macro level to “beat” the micro level. Here, this was done through a principled, well-defined measure of intrinsic cause-eff...

OBJECTIVE To study whether quantitative analysis of M. tuberculosis mRNA could be used to assess bacterial viability. METHODS The levels of M. tuberculosis mRNA were compared 24, 48, and 72 hours after M. tuberculosis H(37)R(V) was treated with no drug, 1.0 micro g/ml and 10.0 micro g/ml rifampicin, 0.2 micro g/ml and 1.0 micro g/ml isoniazid, 2 micro g/ml and 4 micro g/ml ethambutol, 2 micro...

Design complexity of todays microprocessors is increasing at an alarming rate to cope up with the required performance improvement by adopting complicated micro-architectural features such as deep pipelines, dynamic scheduling, out-oforder and superscalar execution, and dynamic speculation. Since verification complexity is directly proportional to the design complexity, considerable amount of t...

This project investigates how the actors in a transportation chain are expected to act when different types of governmental control policies are applied. A simulation-based tool is being developed for use in analyzing the effects of different control policies. The simulator is based on agent technology and include some intelligence with respect to how the transport operators act in different si...

Several problems can arise while developing an interactive or web based systems containing mixture of data access, business logic, and presentation code. Such applications are difficult to maintain, because interdependencies between all of the components cause strong ripple effects whenever a change is made anywhere. High coupling makes classes difficult or impossible to reuse because they depe...

We investigate and model the dynamics of two-dimensional stochastic self-assembly of intelligent micro-systems with minimal requirements in terms of sensing, actuation, and control. A microscopic agent-based model accounts for spatiality and serves as a baseline for assessing the accuracy of models at higher abstraction level. Spatiality is relaxed in Monte Carlo simulations, which still captur...

The multiple realizability of macro-level types does not, in my opinion, prove that “the explanations provided by the macro-theory [in which such types occur] will not, EVEN IN PRINCIPLE, be reducible to a micro-account” (Reconstructing Marxism, p. 120, my emphasis). For multiply-realizable macro-level types may be reducible to highly-complex disjunctions of micro-level types. (Indeed in such c...

PURPOSE Micro-computed tomography (micro-CT) has been widely used in the evaluation of regenerated bone tissue but the reliability of micro-CT has not yet been established. This study evaluated the correlation between histomorphometric analysis and micro-CT analysis in performing new bone formation measurement. METHODS Critical-size calvarial defects were created using a 8 mm trephine bur in ...