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Microarray technology has made available large data sets that can provide information on gene expression when cells are subjected to various treatments. Before proceeding with a formal statistical analysis, many biological and procedural aspects should be considered. These aspects may guide the analysis and subsequent statistical inference. Several of these issues are discussed in connection wi...

Fully Discrete Heterogeneous Multiscale Methods and Application to Transport Problems in Microarrays

A supporting material (as a glass or plastic slide) onto which numerous molecules or fragments usually of DNA or protein are attached in a regular pattern for use in biochemical or genetic analysis. Click here for all chapters

Although microarray experiments have great potential to support progress in biomedical research, results are not easy to interpret. Information about the functions and relations of relevant genes needs to be extracted from the vast biomedical literature. A potential solution is to use computerized text analysis methods. Our proposal enhances these methods with semantic relations. We describe an...

Support Feature Machines (SFM) define useful features derived from similarity to support vectors (kernel transformations), global projections (linear or perceptron-style) and localized projections. Explicit construction of extended feature spaces enables control over selection of features, complexity control and allows final analysis by any classification method. Additionally projections of hig...