abstract background and aim: increased rate of micronucleus in buccal mucosa cells and its correlation with carcinogenesis is worth consideration. recently, occupation in dental laboratories has been proposed as a predisposing factor. therefore, the present study aimed to evaluate the effect of occupational exposure on buccal mucosa cells of dental laboratory technicians. materials and methods:...

The textile printing industry in South India employs a great number of workers that may possibly be exposed to toxic compounds. In the present study, subjects from textile printing units were investigated for the presence of genetic damage in their peripheral blood lymphocytes using micronucleus assay. Proliferation was also investigated using a nuclear division index. It was found that the mic...

OBJECTIVES To determine the cytotoxicity of three commercial mouthrinses Klorhex, Andorex and Tanflex on buccal epithelial cells using micronucleus (MN) test. MATERIALS AND METHODS 28 patients with aged 16-24 undergone three mouthrinses' application were analyzed before and after one week exposure. Physiologic saline was used for the control group. The MN incidence was scored in the buccal ep...

In this study, we investigated the applicability of using in vivo mouse micronucleus (MN) data to derive cancer potency information. We also present a new statistical methodology for correlating estimated potencies between in vivo MN tests and cancer studies, which could similarly be used for other systems (e.g. in vitro vs. in vivo genotoxicity tests). The dose-response modelling program PROAS...

The aim of this study is to determine the level of cadmium contamination in various organs of Snakehead-fish (Ophicephalus striatus). The detected levels of Cd were tested for genotoxic potential in snakehead-fish (SSN-1 cells) cell line by micronucleus assay. To evaluate the SSN-1 cells as a model for genotoxicity study, various concentrations of cadmium were applied to the cells, and the cadm...

The mammalian in vivo micronucleus and sperm morphology assays are widely used as part of the battery of assays for genotoxicity testing required during the development of new drugs. Genotoxicity data on Ciprofloxacin in mammalian system are very limited and mostly contradictory. This study provides more data by assessing the genotoxic potential of ciprofloxacin using mouse micronucleus and spe...

We conducted the micronucleus assay in 3-, 5-, 7-, 9-, 11- and 13-week-old male rats to determine whether the results varied with age. We administered cyclophosphamide orally at 0 (vehicle), 5, 10 or 20 mg/kg, twice, 24 h apart, to five rats per dosage group and collected bone marrow and peripheral blood 24 h after the second treatment. We observed an age-related decrease in micronucleus-induci...

The in vitro micronucleus test (MNT) is a well-established test for early screening of new chemical entities in industrial toxicology. For assessing the clastogenic or aneugenic potential of a test compound, micronucleus induction in cells has been shown repeatedly to be a sensitive and a specific parameter. Various automated systems to replace the tedious and time-consuming visual slide analys...

Fifteen amicronucleate cell lines and 22 cell lines with defective micronuclei were obtained following selective laser microbeam irradiation of the micronucleus. The amicronucleate cell lines showed reduced growth rate and formed abnormal oral apparatuses in asexual reproduction, and failed to produce any oral apparatus in autogamy, in agreement with previous observations on amicronucleate cell...