The antimicrobial agent cetylpyridinium chloride (CPC) which is used in therapy of oro-pharyngeal infections and for antiseptic treatment of the oral cavity is active against different bacterial species. Determination of the minimal inhibitory concentration (MIC) using the agar dilution technique revealed that the gastric pathogen Helicobacter pylori in vitro is highly susceptible to CPC as ind...

By far, only tigecycline, colistin, and some aminoglycosides still show favorable in vitro activities against carbapenem-resistant Enterobacteriaceae. However, rapid emergence of resistance often occurs during long-term treatment in clinic, challenging these last resort antimicrobials. In this study, we measured mutant prevention concentration (MPC) and mutant selection window (MSW) of tigecycl...

BACKGROUND AND PURPOSE Antibiotic combinations are used to enhance antibacterial efficacy and to prevent the development of resistance. In this study, the in vitro activities of antibiotic and phytochemical combinations against Pseudomonas aeruginosa were tested by the fractional inhibitory concentration method, derived from the minimal inhibitory concentrations (MICs) of the agents in combinat...

Effectiveness of disinfectant MA-T against Escherichia coli in various growth media was demonstrated by minimal inhibitory concentration (MIC). MIC (DM+1/100 volume LBG [Luria-Bertani medium with 0.4% glucose]) at pH 6.5 and 8.5 2.5 μg/mL, that 100%LBG 7.5 μg/mL 10 respectively. is not markedly affected organic materials or pH. HClO DM+1/100LBG 12.5 respectively, but rich (100%LBG) 300 500 indi...

Due to the emergence of bacterial resistance in phytopathogenic microorganisms, it is necessary search for new treatment alternatives these pathogens. Natural extracts are a potential source bioactive compounds that can act against such strains. The antibacterial activity Larrea tridentata bacteria with public health importance has been documented; however, few reports cover pathogens associate...

Cinnamaldehyde (CA) is marginally soluble in water, making it challenging to evenly disperse it in foods, and resulting in lowered anti-A. flavus efficacy. In the present study, nano-dispersed CA (nano-CA) was prepared to increase its aqueous solubility. Free and nano-dispersed CA were compared in terms of their inhibitory activity against fungal growth and aflatoxin production of A. flavus bot...

The minimum inhibitory concentration (MIC) of an antimicrobial drug for a bacterial pathogen is used as a measure of the bacterial susceptibility to the drug. However, relationships between the antimicrobial concentration, bacterial susceptibility, and the pharmacodynamic (PD) inhibitory effect on the bacterial population are more complex. The relationships can be captured by multi-parameter mo...

Oral candidiasis causes pain in oral cavity or tongue. Antifungal drugs are commonly used for the treatment of candidiasis, however, there could be several problems such as side effects, drug resistance, or contraindication to concomitant use with drugs already taken. The development of substituting antimicrobial agents, which could be used internally or as gargling agents, is expected. Some es...