The capacity of the vasodilating drugs, minoxidil and hydralazine, for inducing renin release was characterized in rats according to chronology and dose response. Propranolol inhibition of this renin release was also characterized and related to serum levels of propranolol. Minoxidil and hydralazine (1.0 mg/kg) induced sevenfold elevations of serum renin activity. Treatment with propranolol, re...

Androgenetic Alopecia (AGA) is the most common cause of alopecia in males and females. Minoxidil finasteride are only FDA approved treatments for AGA. New including Platelet Rich Plasma (PRP) microneedling have shown promising results. The purpose this literature review to highlight recent studies examining effects topical minoxidil combined with PRP or monotherapy. method used paper include a ...

<p><strong>Background:</strong> Minoxidil and finasteride are most common drugs used in androgenetic alopecia. The objective of the study was to know efficacy topical minoxidil solution with without finasteride.</p><p><strong>Methods:</strong> In total about 30 subjects, aged 18-45 years, who came for outpatient consultation male pattern alopecia were r...

ATP-sensitive potassium (KATP) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. There has been considerable interest in exploring KATP channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. The purpose of this study was to synthesize 3,3,6,6-tet...

Objective: Although azelaic acid is effective for treatment of acne and rosacea, the biological activity of azelaic acid and the effect of its combination therapy with minoxidil were not elucidated with regard to hair growth. Materials and Methods: In this study, mouse vibrissae follicles were dissected on day 10 after depilation. Then, the bulb and bulge...

Background: Minoxidil is an antihypertensive agent and vasodilator which may help to promote local blood flow thus hastening the closure of excisional skin wounds. Corticosteroids down-regulate wound healing. This work aims develop characterize nanofiber-eluting dexamethasone minoxidil investigate their effect on healing in a rat model. Methods: dexamethasone-loaded dressings were developed cha...

Alopecia is a dermatological disorder, commonly known as hair loss, which affects up to half of the Caucasian male population by middle age, and almost all (95%) Caucasian men by old age. Considering that alopecia affects so many people and that there is currently no scientifically proven treatment with few side effects, new drug-delivery systems able to improve alopecia therapy are urgently re...