This work analyzes the dispersion of two highly hydrophobic actives, (9Z)-N-(1,3-dihydroxyoctadecan-2-yl)octadec-9-enamide (ceramidelike molecule) and 2,6-diamino-4-(piperidin-1-yl)pyrimidine 1-oxide (minoxidil), using oil-in-water nanoemulsions with aim preparing stable safe aqueous-based formulations that can be exploited for enhancing penetration active compounds through cosmetic substrates....

Vasodilators lower the blood pressure by decreasing total peripheral resistance. The hemodynamic changes depend on the mix between arteriolar and venous dilatation. Since the compensatory responses are blunted with sympatholytic agents and diuretics, vasodilators can be applied effectively in the treatment of hypertension. Hydralazine and prazosin are used as step III drugs in combination with ...

BACKGROUND The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly. OBJECTIVE The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia. METHOD T...

Introdução: A alopecia androgenética (AAG) é caracterizada pela queda capilar atrelada a androgênios, associada diminuição do diâmetro, comprimento e pigmento fio de cabelo, que se manifesta com o decorrer da idade, em maior proporção após terceira década vida na maioria das pacientes sexo feminino. Neste relato caso, apresentamos paciente obteve diagnóstico AAG sua segunda vida, sendo submetid...

Alopecia areata is a common form of immune-mediated alopecia in which autoimmune attack the hair follicles causes loss without scarring, characterized by appearance round, hairless areas on scalp. Current treatments including glucocorticoids (topical, intralesional, and systemic), minoxidil, anthralin, other immunosuppressive agents, contact immunotherapy have variable efficacy for severe disea...

Telogen effluvium (TE) is one of the most common causes diffuse nonscarring hair loss. A number factors have been implicated in causation TE, however, clear evidence their support lacking. The role stress as a causative factor well result loss needs to be adequately understood. can occur people any age, gender, and racial background. both men women, although women greater tendency experience th...