there are many reports for involvement of atp-sensitive potassium channels in pancreatic, cardiac and vascular smooth muscle cells. this study examined the effect of single doses of k+ channel openers diazoxide, minoxidil and k+ channel blockers chlorpropamide, glibenclamide on serum concentration of aldosterone in male rats. blood samples were obtained 60 minutes after drug treatment and serum...

ATP-sensitive potassium channels (K(ATP)) in the thick ascending limb of the loop of Henle play an important role in apical K(+) recycling, a mechanism essential for maintaining the activity of the Na/2Cl/K-cotransporter. We have previously demonstrated that inhibition of K(ATP) decreases Na(+) and K(+) absorption in the loop of Henle and induces diuretic and natriuretic effects. In the present...

1. Twelve patients with essential hypertension were treated aggressively with minoxidil in order to achieve blood pressure control as rapidly as possible. 2. After an initial dose of 5 mg, dose increments were administered 6 hourly until a fall in blood pressure was observed. 3. The size of additional doses was determined by the magnitude of and response to the lowest effective dose and the the...

Hairs play an important role in personality and always remained the center of attraction. Beautiful hairs are considered as parameter beauty, people very conscious about hair, they search good remedy for maintaining their hairs. Indralupta (Alopecia Areata) is acquired skin aliment that can affect all hair bearing including scalp, beard which characterized by localized areas non-scarring loss b...