Fig 1. Patient 1. Dermascopic image of the occipital scalp shows numerous broken hairs. Beaded hairs pathognomic of monilethrix can be seen. INTRODUCTION Monilethrix is an autosomal dominant genodermatosis characterized by hair fragility, keratosis pilaris, and pathognomonic beading of the hair shaft. Hair fragility may lead to hair breakage and the appearance of generalized hair loss. The gene...

A significant number of men and women experience hair loss. Up to 80% white 40% 50% are affected at some point in their lives. White more likely loss than other ethnicities. Many factors potentially contribute loss, including hormonal changes, physiologic stress, chronic illnesses, medications, dietary genetics, local trauma. People by often low self-esteem; personal, social, work-related chall...

BACKGROUND Thuja orientalis has been traditionally used to treat patients who suffer from baldness and hair loss in East Asia. The present study sought to investigate the hair growth-promoting activity of T. orientalis hot water extract and the underlying mechanism of action. METHODS After T. orientalis extract was topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, the h...

BACKGROUND Cuscuta reflexa (Roxb.), Citrullus colocynthis (Schrad.), and Eclipta alba (Hassk.) are traditionally acclaimed herbs for their hair growth-promoting potential. Aim In the present study, it was envisaged to prepare herbal formulations containing petroleum ether extracts of the three herbs in varying ratio and evaluating the formulations for the hair growth-promoting activity. METHO...

The relaxing effects of the adenosine 5'-triphosphate (ATP)-sensitive K' channel openers (KATp openers; diazoxide, minoxidil, pinacidil, (± )-cromakalim, (+)-cromakalim and (-)-cromakalim) were investigated on the resting tone of pig proximal urethra. In addition, patch-clamp techniques were utilized for recording cromakalim-induced ionic currents in cells dispersed from the same urethral regio...

Prostacyclin synthase (PGIS) is a cytochrome P450 (P450) enzyme that catalyzes production of prostacyclin from prostaglandin H(2). PGIS is unusual in that it catalyzes an isomerization rather than a monooxygenation, which is typical of P450 enzymes. To understand the structural basis for prostacyclin biosynthesis in greater detail, we have determined the crystal structures of ligand-free, inhib...

A 20-year-old woman presented with malignant hypertension, pulmonary edema, anemia, and azotemia. Blood pressure was adequately controlled only after progressively more intensive drug regimens, finally including minoxidil, nadolol, and furosemide. On these drugs, the patient developed progressive left and right heart failure, anasarca, and malnutrition. The control of hypertension, heart failur...