AIM Anal fissures are associated with hypertonia of the internal anal sphincter and pain. We evaluated the efficacy of local application of a combination of minoxidil and lignocaine in healing anal fissures. METHODS In this prospective, randomized, double-blind study, 90 patients with anal fissure were recruited. Patients received local applications of ointments containing 5% lignocaine (n=28...

We report a case of a 2 year-old male patient who developed generalized hypertrichosis after 2 months of treatment with 5% minoxidil foam for alopecia areata. This report highlights the danger of prescribing  topical minoxidil to young children and the need to correctly instruct caretakers about its administration.

The study describes the synthesis and characterization of zinc(II) minoxidil nanocomposite (1). The reaction between zinc(II) acetate, minoxidil, {C9H15N5O=minoxidil=(2,4-diamino-6-piperidine-1-yl) pyrimidine N-oxide)} as a ligand and KI as bridging agent, in methanol at 60°C leads to the formation of nano-sized Zn(II) minoxidil nanocomposite, 1. Characterization of (1) was carried out by eleme...

The electrochemical behavior and amperometric-FIA quantification of minoxidil at a glassy carbon electrode is described. The procedure is based on electrochemical oxidation at 0.800 V (vs. Ag/AgCl/NaCl(3 M) in a phosphate buffer solution. Minoxidil was determined over the range 1 x 10(-7) - 1 x 10(-4) M. Different analytical parameters and electrode stability were analyzed to obtain the best el...

1. Thirty moderately severely hypertensive patients were studied in a double-blind comparison of minoxidil and hydrallazine in combination with frusemide and propranolol. 2. Blood pressure control in both groups of patients was satisfactory but long-term control appeared to be better in the minoxidil group. 3. Renal function was well preserved in both groups. Evidence of cardiac hypertrophy was...

The present study has been designed to investigate the effect of piracetam on morphine/ buprenorphine-induced antinociception in rats and effect of piracetam on morphine or minoxidil induced relaxation in KCl-precontracted isolated rat aortic ring preparation. Nociceptive threshold was measured by the tail flick test in rats. The cumulative dose responses of morphine or minoxidil were recorded ...

Minoxidil dissolved in propylene glycol/ethanol/water (20: 60: 20; v/v) was more efficiently delivered into hairless mouse skin from a 0.02% solution than from a 2% formulation during in vitro mass balance experiments. Evaporation of the vehicle after application of the 2% minoxidil solution led to compositional changes so drastic that saturation is attained quickly. The shifting compositions o...

The hypotensive efficacies of two vasodilators, hydralazine and minoxidil, were assessed as these drugs were used individually in combination with beta-adrenergic blockade and diuretics in 11 hypertensive patients in whom elevated blood pressure had not been adequately controlled previously by other antihypertensive therapy. Control supine blood pressure fell from 191/128 mm Hg on propranolol a...

Introduction: Alopecia Areota is a chronic inflammatory disease that involves hair follicles, and sometimes nails, caused by T-cell mediated autoimmune mechanism. Current treatment modalities includes corticosteroids (oral, topical or intralesional), Minoxidil, Contact sensitizers like DNCB, DPCP and SADBE, Immunosuppressants like Methotrexate or Azathioprine, DMARDs like Sulfasalazine, and Pho...

Introduction Minoxidil is a powerful vasodilator hypotensive drug which has been used extensively to control blood pressure in patients with renal failure. Pericardial effusions are associated with minoxidil therapy (Marquez-Julio and Uldall, 1977). In cases where the protein content of the effusion has been examined in patients-some on dialysis-(Martin, Spodick and Zins, 1980; Houston, McChesn...