Context Trends toward more conservative management of papillary thyroid cancer (PTC) diminish the primacy of serum thyroglobulin (Tg) assays as a posttreatment surveillance tool. Objective To identify thyroid tumor-associated microRNAs (miRNAs) in the serum with potential for development as unique biomarkers of PTC recurrence. Methods We measured expression of 754 miRNAs in serum samples co...

During the past decade, 3ʹ untranslated regions (3ʹUTRs) of mRNAs continue to emerge as important sites for gene regulation due to the binding of microRNAs (miRs), RNA-binding proteins (RBPs) and possibly other trans-acting factors. Brain derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) play important roles inside and outside the central nervous system (...

We have hypothesized that dietary modulation of intestinal non-coding RNA [microRNA (miRNA)] expression may contribute to the chemoprotective effects of nutritional bioactives (fish oil and pectin). To fully understand the effects of these agents on the expression of miRNAs, Sprague-Dawley rats were fed diets containing corn oil or fish oil with pectin or cellulose and injected with azoxymethan...

The discovery and characterization of blood-based disease biomarkers are clinically important because blood collection is easy and involves relatively little stress for the patient. However, blood generally reflects not only targeted diseases, but also the whole body status of patients. Thus, the selection of biomarkers may be difficult. In this study, we considered miRNAs as biomarker candidat...

Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be detected in blood. We aimed to establish definitive proof-of-principle that circulating microRNAs are differentially affected during sepsis and non-in...

BACKGROUND The surrogate markers of HIV/AIDS progression include CD4 T cell count and plasma viral load. But, their reliability has been questioned in patients on anti-retroviral therapy (ART). Five microRNAs (miRNAs) - miR-16, miR-146b-5p, miR-150, miR-191 and miR-223 in peripheral blood mononuclear cells (PBMCs) were earlier found to assign HIV/AIDS patients into groups with varying CD4 T cel...

Background: microRNAs (miRNAs) are small non-coding RNAs that can ignite the degradation of mRNAs or inhibit protein translation and therefore essential for several physiological pathological functions. miRNAs regulate up to 60 % human mRNA, including genes related cartilage development, homeostasis, OA pathology. For example, miR-9 inhibits matrix metalloproteinase 13 miR-140 expression level ...