It has been demonstrated that there are abundant stable microRNAs (miRNAs) in plasma/serum, which can be detected and are potentially disease specific. However, the lack of suitable endogenous controls for serum miRNA detection is the restriction for the widely usage of this kind of biomarkers and for the between-laboratory comparison of the findings. We first systematically screened for endoge...

MicroRNAs (miRNAs) are small RNAs of 19 to 25 nucleotides that are negative regulators of gene expression. To determine whether miRNAs are associated with cytogenetic abnormalities and clinical features in acute myeloid leukemia (AML), we evaluated the miRNA expression of CD34(+) cells and 122 untreated adult AML cases using a microarray platform. After background subtraction and normalization ...

Cis-antisense gene pairs (CASGPs) can transcribe mRNAs from an opposite strand of a given locus. To classify and understand diverse CASGP phenomena in the human we compiled a genome-wide catalog of CASGPs and integrated these sequences with microarray, SAGE and miRNA data. Using the concept of overlapping regions and clustering of SA transcripts by chromosome coordinates, we identified up to 90...

AMA Guz M, Mądro A, Cybulski Jeleniewicz W, Kozicka J, Kurzepa J. Korelacje miR-1290 i miR-191-5p z parametrami laboratoryjnymi jako przydany test do różnicowania raka trzustki przewlekłego zapalenia trzustki: badanie wstępne. Medical Studies/Studia Medyczne. 2023;39(2):114-121. doi:10.5114/ms.2023.129039. APA Guz, M., Mądro, A., Cybulski, Jeleniewicz, W., Kozicka, J., & Kurzepa, (2023). Medycz...

BACKGROUND MicroRNAs (miRNAs) consist of a group of small noncoding RNAs that partially regulate gene expression. We investigated the expression patterns of commonly deregulated miRNAs in Crohn's disease (CD) and ulcerative colitis (UC) in peripheral blood samples of inflammatory bowel disease patients. PATIENTS AND METHODS This study consisted of 128 CD and 88 UC patients, as well as 162 hea...