Abstract Background Pericoronary adipose tissue (PCAT) plays a key role in the pathogenesis of atherosclerosis. PCAT is source microRNAs (miRs) that acts as messengers for intercellular communication. In this study, we investigated whether surrounding coronary occlusive atherosclerotic lesions shows specific miR expression patterns compared to plaque-free segments. Purpose To evaluate miRs are ...

Objective(s): Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder characterized by the accumulation of myeloid cells with a chromosomal translocation known as the Philadelphia chromosome. In this study, we investigated the roles of miR-570 in CML development. Materials and Methods: Expression of miR-570 in CML samples and cell lines was determined by qRT-PCR. Glucose upt...

MicroRNAs are non-coding RNAs. Studies have shown that miRNAs are expressed aberrantly in stroke. MiR-1 enhances ischemic damage, and previous study has demonstrated that reduction of miR-1 level has neuroprotective effect on Middle Cerebral Artery Occlusion(MCAO). Since apoptosis is one of the important process in neural protection, possible effect of miR-1 on this pathway has been tested in t...

Abstract Objective To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment. Methods IL-1? (10 ng/mL) LPS (1 ?g/mL) was used to construct cell models with A549 cells; performed better against LPS. Different concentrations of Dex were attenuate inflammation induced by IL-1?, its effect assessed via RT-PCR detect cytokine-related...

micrornas are highly conserved small non-coding regulatory rnas that involve in post transcriptional regulating of gene expression during different cellular mechanisms. aberration of mir-218 expression during tumorigenesis of different solid tumors has been reported by numerous studies. in current systematic review article, by using the terms “mir-218” and “cancer” we first searched for english...

Abstract Objectives Because acute myocardial infarction (AMI) may occur suddenly and cannot be predicted, it is critical to identify early diagnosis markers. In recent years, in addition the developing diagnostic methods, other markers that related of AMI are miRNA molecules. The specificity miRNAs involved pathogenesis atherosclerosis regulation cardiac functions has been shown. present study ...

objective(s):mir-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (gct) of bone remains poorly understood. the current study aimed to investigate the potential role and mechanism of mir-125b in gct. materials and methods:expression levels of mir-125b in gct tissues were determined using rt-pcr. the cell proliferation was surveyed by direct cell coun...

Background: One of the most remarkable processes during spermatogenesis is the drastic change in gene expression. It has been recently proposed that small RNAs such as micorRNAs (miRNAs) contribute a great deal of function in regulation of the gene expression in sperm. Alterations in miRNAs function prove to be detrimental to proper spermatogenesis. As many patients suffer from idiopathic infer...