Predictive biomarkers for early diagnosis of prostate cancer are important its treatment. The functional microRNAs in the exosomes plasma and serum samples interest as stable non-invasive recurrence patients. present study aimed to clarify value exosomal miRNA-125a-5p miR-141-5p cancer. included 19 healthy individuals 31 In comparison levels controls, showed a slight increase patients (p=0.085)...

AIM We investigated the differential miRNA expression in pituitary adenomas (both non-functioning and gonadotropin-secreting) and normal pituitaries. MATERIAL AND METHODS RNA was extracted and purified from pituitary adenomas (10 non-functioning and 10 gonadotropin-secreting) and from two normal pituitary tissue samples. The samples were analyzed by miRNA microarray. Gene expression was measu...

Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision has emerged as the standard treatment for locally advanced rectal cancer (LARC) patients. However, many cases do not respond to neoadjuvant CRT, suffering unnecessary toxicities and surgery delays. Thus, identification of predictive biomarkers for neoadjuvant CRT is a current clinical need. In the present study, microRNA-...

Expressed polycistronic microRNA (miR) cassettes have useful properties that can be utilized for RNA interference (RNAi)-based gene silencing. To advance their application we generated modular trimeric anti-hepatitis B virus (HBV) Pol II cassettes encoding primary (pri)-miR-31-derived shuttles that target three different viral genome sites. A panel of six expression cassettes, comprising each o...

Article history: Received 31 October 2016 Accepted 1 November 2016 Available online 9 November 2016 (both miR-675-5p and miR-675-3p) expression in clinical samples. MiR-675-5p was undetectable in TCGA samples, while miR-675-3p expression correlated with H19 levels, but was no predictor either for overall or disease-free survival. At least in their model system that Calin and coworkers used, H19...

Contact allergy to at least one allergen is common in the European population with a prevalence of 27%. It can develop into allergic contact dermatitis (ACD), which an inflammatory skin condition characterized as delayed-type hypersensitivity reaction manifesting rash and it known that allergen-specific tissue-resident memory CD8+ T (TRM) cells are important development ACD. has been previously...