Background: The goal of treatment for patients with RA is achieve to remission, or at least a state low disease activity. Exercise recommended in addition drug therapy. It has been found be effective greatly improving functionality and reducing cardiovascular risk without exacerbating Therefore, it that all should encouraged include aerobic resistant exercise training as part their routine (1)....

Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cells, contributing to carcinogenesis tumour microenvironment. Recent studies have revealed that CAFs, normal cells all secrete exosomes contain miRNA, establishing cell-cell communication network within For example, miRNA dysregulation melanoma has been shown promote CAF activation via induction of e...

results treatments through mirnas can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. conclusions further work is needed to be done to make mirna treatments available to large number of people suffering from various bone diseases. context mirnas can regulate the expression of genes by interfering in their mrnas, acting as key regulators of diverse cell...

background: micrornas (mirna) are small non-coding rnas that have a distinguished role in post- transcriptional gene expression. it’s estimated that 10-30% of human mrnas are regulated by mirnas. many mirnas profiles change during normal erythropoiesis in which some of them are stage specific.mir-155 was downregulated 200 fold in erythropoiesis. materials and methods: k562cells were grown in rp...

objective: micro-rnas (mirnas) are a class of posttranscriptional regulators that play crucial roles in various biological processes. emerging evidence suggests a direct link between mirnas and development of several diseases including type 2 diabetes (t2d). in this study, we aimed to investigate the effect of predicted mirna and target genes on insulin resistance. materials and methods: this e...

MicroRNAs (miRNAs) are short, endogenous non-coding RNAs that function as guide molecules to regulate transcription of their target messenger RNAs. Several methods including low-density qPCR arrays are being increasingly used to profile the expression of these molecules in a variety of different biological conditions. Reliable analysis of expression profiles demands removal of technical variati...

Objective(s): Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. Materials and Methods: In the current study, we built a vascular calcification rat mode...