Two genes are synthetically lethal (SL) when defects in both are lethal to a cell but a single defect is non-lethal. SL partners of cancer mutations are of great interest as pharmacological targets; however, identifying them by cell line-based methods is challenging. Here we develop MiSL (Mining Synthetic Lethals), an algorithm that mines pan-cancer human primary tumour data to identify mutatio...

Gram-negative bacterial proteins which are exported from the cytosol to the external environment by the type V secretion system are also known as autotransporters. Once translocated to the periplasmic compartment by the sec-dependent general secretory pathway, their C-terminal domain forms a pore through which the N-terminal domain travels to the outer membrane without the need of other accesso...

The purpose of this cross-sectional study was to determine the differences in narrative macrostructure abilities children different age groups using a progress monitoring tool based discourse theory. A majority existing research regarding developmental patterns has been schema Monitoring Indicators Scholarly Language (MISL) rubric is theory and designed characterize aspects proficiency school-a...

On the Language Design and Semantic Foundation of LCL a Larch C Interface Speci cation Language The specialization of a speci cation language to a particular programming lan guage is an important characteristic of module interface speci cation languages MISL s The only well developed MISL s are the Larch interface languages and among these LCL a Larch C interface speci cation language would see...

Le sésame constitue le deuxième produit d’exportation agricole au Burkina Faso mais sa qualité n’est pas toujours satisfaisante à cause de la présence d’impuretés et parfois microorganismes pathogènes notamment les salmonelles. La présente étude a pour objectif d’évaluer prévalence des salmonelles dans ses produits dérivés. Au total, 107 échantillons dont 73 graines 34 dérivés (biscuits, croque...

Several novel thiol-reactive clenbuterol analogues were coupled in high yield with bovine serum albumin (BSA). After labelling of unreacted cysteines with maleimide spin label (MiSL), the yield of the coupling reaction was determined by electron paramagnetic resonance (EPR) spectroscopy and spectral analysis. Two spin-probe populations with different mobility states were quantitatively determin...