HspBP1 belongs to a family of eukaryotic proteins recently identified as nucleotide exchange factors for Hsp70. We show that the S. cerevisiae ortholog of HspBP1, Fes1p, is required for efficient protein folding in the cytosol at 37 degrees C. The crystal structure of HspBP1, alone and complexed with part of the Hsp70 ATPase domain, reveals a mechanism for its function distinct from that of BAG...

The Large Hadron Collider, a 7⊕7 TeV proton-proton collider under construction at CERN (the European Laboratory for Particle Physics in Geneva), will take experiments squarely into a new energy domain where mysteries of the electroweak interaction will be unveiled. What marks the 1-TeV scale as an important target? Why is understanding how the electroweak symmetry is hidden important to our con...

Electromagnetically bound π±K∓-pairs (πK-atoms) have been observed by the DIRAC-II experiment at the CERN-PS. The πK-atoms were produced by the 24 GeV/c proton beam impinging on a thin Pt-target. The π±and K∓-mesons from the atom dissociation were analyzed in a two-arm magnetic spectrometer. An enhancement was observed at low relative momentum, corresponding to the production of 173 ± 54 πK-ato...

A pair of bpe-H(+) ligands in a zwitter-ionic complex undergoes photochemical cycloaddition quantitatively accompanied by proton transfer and the cyclobutane ring isomerizes slowly in solution to two more isomers, catalyzed by CF(3)CO(2)H acid.

The proton-nucleon cross section ratio R = Br(Υ → l+l−) · dσ(Υ)/dy|y=0 /σ(J/ψ) has been measured with the HERA-B spectrometer in fixed-target proton-nucleus collisions at 920 GeV proton beam energy corresponding to a proton-nucleon cms energy of √ s = 41.6 GeV. The combined results for the decay channels Υ → e+e− and Υ → μ+μ− yield a ratio R = (9.0±2.1) ·10−6 . The corresponding Υ production cr...

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The equations of classical spin-orbit motion can be extended to a Hamiltonian system in 9-dimensional phase space by introducing a coupled spin-orbit Poisson bracket (18) and a Hamiltonian function (20). After this extension and by establishing connections between initial and extended systems it becomes possible to apply the methods of the theory of Hamiltonian systems to the study of polarized...

Genetically encoded fluorescent cross-linking agents represent powerful tools useful both for visualising and modulating protein interactions in living cells. The far-red fluorescent protein HcRed, which is fluorescent only in a dimer form, can be used to promote the homo-dimerisation of target proteins, and thereby yield useful information about biological processes. We have in yeast cells exp...

Yme1p, an ATP-dependent protease localized in the mitochondrial inner membrane, is required for the growth of yeast lacking an intact mitochondrial genome. Specific dominant mutations in the genes encoding the alpha- and gamma-subunits of the mitochondrial F(1)F(0)-ATPase suppress the slow-growth phenotype of yeast that simultaneously lack Yme1p and mitochondrial DNA. F(1)F(0)-ATPase activity i...