This article discusses solving non-linear programming problems containing integer, discrete and continuous variables. A novel mixed integer-discrete-continuous, non-linear optimization method based on Differential Evolution algorithm is described. Also the required handling techniques for integer, discrete and continuous variables are described including the techniques needed to handle boundary...

Over the past few decades, neuroscience experiments have become increasingly complex and naturalistic. Experimental design has in turn more challenging, as must conform to an ever-increasing diversity of constraints. In this article, we demonstrate how process can be greatly assisted using optimization tool known mixed-integer linear programming (MILP). MILP provides a rich framework for incorp...