Musladin-Lueke syndrome (MLS), previously termed Chinese Beagle syndrome, is an autosomal-recessive connective tissue disorder characterized by extensive fibrosis of the skin and joints that was first identified in Beagles in the 1970s. Recent research identified a founder mutation (c.660C>T; p.R221C) in the ADAMTSL2 gene in Beagles with MLS. Here, we report the detailed clinical phenotype and ...

In this paper a new technique aimed to obtain accurate estimates of the error in energy norm using a moving least squares (MLS) recovery-based procedure is presented. We explore the capabilities of a recovery technique based on an enhanced MLS fitting, which directly provides continuous interpolated fields, to obtain estimates of the error in energy norm as an alternative to the superconvergent...

Since protection and assurance are the primary concerns in MLS databases, performance has often been sacri ced in some known MLS database approaches. Motivated by performance concerns, a replicated architecture approach which uses a physically distinct backend database management system for each security level is being investigated. This is a report on the behavior and performance issues for th...

Microphthalmia with linear skin defects (MLS) is an X-linked dominant, male-lethal syndrome characterized by microphthalmia, aplastic skin and agenesis of the corpus callosum, and is caused by the deletion of a 500 kb critical region in Xp22.3. Our laboratory isolated a novel rho GTPase-activating protein (rhoGAP) gene named ARHGAP6 from the MLS region. ARHGAP6 contains 14 exons encoding a 974 ...

[1] TES (Tropospheric Emission Spectrometer) nadir and MLS (Microwave Limb Sounder) limb measurements from the Aura satellite are used to jointly estimate an atmospheric carbon monoxide (CO) profile with extended vertical range compared to profiles retrieved from the individual measurement. We describe the algorithms, the processing procedures, the prototyping results, and the evaluations for t...

[1] Ozone profiles from the Microwave Limb Sounder (MLS) onboard the Aura satellite of the NASA’s Earth Observing System (EOS) were experimentally added to the European Centre for Medium-range Weather Forecasts (ECMWF) four-dimensional variational (4D-var) data assimilation system of version CY30R1, in which total ozone columns from Scanning Imaging Absorption Spectrometer for Atmospheric CHart...

Metadatabase modeling and design integrate process modeling and data modeling methodologies. Both are core topics in the information technology (IT) curriculum. Learning these topics has been an important pedagogical issue to the core studies for management information systems (MIS) and computer science (CSc) students. Unfortunately, the learning curve for the associated metadatabase modeling m...

The role of non-H-2 alloantigens, specifically Mls locus products, in secondary in vitro T-cell-mediated cytotoxicity has been studied. Splenic T lymphocytes, activated against Mls locus alloantigens in primary-mixed cultures and isolated by velocity sedimentation gradient separation techniques, were used as responding populations in secondary mixed leukocyte cultures (MLCs) and cell-mediated l...

Although typical mixed lymphocyte reactions (MLR) 1 are directed predominantly to H-2 determinants , high pr imary MLR in mice can also be elicited by gene products o f the minor lymphocyte-stimulating (Mls) locus located on chromosome 1 (1). O f the four described Mls alleles, a b c d, Mis a and Mls d determinants elicit the strongest response. Since these two sets of determinants cross-react ...

The transplantation of pancreatic islets (PIs) containing insulin producing beta cells is considered an alternative approach for the treatment of type 1 diabetes mellitus (T1DM) [1]. Currently, different transplantation sites are assessed in clinical trials to improve outcome [2, 3]. To better monitor and validate the success of transplantation, it is desirable to monitor the location of engraf...