background: lipophosphoglycan 3 (lpg3) is required for the lpg assembly, a well known virulent molecule. in this study, the lpg3 gene of the lizard and mammalian leishmania species were cloned and sequenced. a three-dimensional structure (3d) for the target sequence was also predicted by comparative (homology) modeling. materials and methods: an optimization pcr amplification was performed on g...

background: luxi is a component of the quorum sensing signaling pathway in vibrio fischeri responsible for the inducer synthesis that is essential for bioluminescence. methods: homology modeling of luxi was carried out using phyre2 and refined with the galaxyweb server. five models were generated and evaluated by errat, anolea, qmean6, and procheck. results: five refined models were generated b...

medicinal use of the opium poppy (papaver somniferum l) has ancient history, but the isolation of morphine was not described until the early nineteenth century. morphine is the most important alkaloid of opium poppy in the last 50 years. in the morphine pathway has been reported to generate morphine in this species, codm has a crucial role as the gene coding the enzyme responsible for demethyla...

in the present work, the extraction of zinc from a sphalerite concentrate using sodium nitrate as an oxidant in a sulfuric acid solution was investigated. the effective parameters such as the temperature, sulfuric acid and sodium nitrite concentrations, stirring speed, particle size, and solid/liquid (s/l) ratio were analyzed. the dissolution rate increased with increase in the sulfuric acid an...

introduction: today, with development of various industries, the adverse events originated from explosion and emission of toxic and chemical substances have increased. these events may cause serious environmental problems that threaten human health and safety. therefore, knowledge about the risk of toxic substances from industrial facilities is essential. although, chlorine is extensively utili...

abstract- bruising degrades the quality of fresh apple fruits. reducing bruise damage is of utmost importance in designing and developing processing equipments. the main objective of the present study was to introduce an analytical method to predict the allowable static load applicable to apple fruits. to predict the strain energy absorbed by the fruit, a point load was applied on the solid sph...

abstract the results of an integrated study aimed at restoring water quality in a large watershed including seven catchments in north east iran are presented in this paper. this case study demonstrates how landscape metrics reflect direct or surrogate causes of the land use practices that are the determinants of water quality parameters. water quality factors included ec, ph, cl-1, hco3-1, so4-...

cancer is a leading cause of death worldwide. despite the availability of several chemotherapeutic drugs, there is still a great need for more efficient agents for a better management of cancer. in this contribution, a series of 11 dhps (4a, 4b & 7a-i) were synthesized and evaluated for their cytotoxic effect against mcf-7, ls180, and molt-4 cancer cell lines using mtt assay. synthesized 2,6-di...

contraceptive patches have become a frequently used contraceptive method. we present a mathematical model that describes the serum concentration profiles of norelgestromin (ngmn) and ethinylestradiol (ee) released from the contraceptive patch ortho evra®. we propose a simple one-compartment model based on pharmacokinetics data reported in previous studies. the model assumes a time-dependent rel...

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