Epigenetic marks are extensively altered in cancer but may also change in normal tissues with age, which is the primary risk factor for most cancers. We conducted an epigenome-wide study to identify age-related methylation sites and examine their relationship to cancer and other underlying epigenetic marks. We analyzed 1006 blood DNA samples of women aged 35-76 years from the Sister Study and f...

A flexible strategy for the preparation of nanostructures of gold nanoparticles (AuNPs) through DNA directed assembly has been proposed. This strategy would greatly enhance the stability, precision and flexibility in the construction of DNA-base structural and functional devices, and promote the development of DNA nanotechnology.

This research examines the impact of a nutrition education intervention program on the nutritional status and knowledge of Nicaraguan adolescent girls. Anthropometric measurements, hemoglobin values, and data concerning nutritional knowledge were collected from adolescent girls living in Managua, Nicaragua. Using a pre-test/post-test design, data are compared prior to and after the nutrition in...

Proper dietary management is essential to pet health, yet changing pet owners' feeding practices is often difficult. Taking a diet history provides an opportunity to open a dialogue about animals' dietary needs as well as invaluable information that will aid in tailoring specific dietary interventions to the needs and preferences of patients and their caregivers.

HE analysis of adult phenotypic differences resulting from experimental or genetic modification of a developing system sometimes yields a useful description of the course of development in that system. Such a description may include, explicitly or not, the ontogenies of the ultimate character differences; therefore, it is desirable that the basic information should include the morphological fac...

OBJECTIVES To describe a conceptual framework to assist in the application of capacity-building principles to public health nutrition practice. DESIGN A review of the literature and consideration of the determinants of effective public health nutrition practice has been used to inform the development of a conceptual framework for capacity building in the context of public health nutrition pra...

This paper estimates a height production function using data from a randomized nutrition intervention conducted in rural Guatemala from 1969 to 1977. Using the experimental intervention as an instrument, the IV estimates of the effect of calories on height are an order of magnitude larger than the OLS estimates. Information from a unique measurement error process in the calorie data, counterfac...

Transcription activator-like effector (TALE) proteins are a class of programmable DNA-binding proteins used extensively for gene editing. Despite recent progress, however, little is known about their sequence search mechanism. Here, we use single-molecule experiments to study TALE search along DNA. Our results show that TALEs utilize a rotationally decoupled mechanism for nonspecific search, de...

BACKGROUND Evaluations of large-scale health and nutrition programmes in developing countries are needed for determining the effectiveness of interventions. This article critically analyses a non-governmental organization (NGO)-led large-scale, multi-country, 10-year micronutrient and health (MICAH) programme with an 'adequacy evaluation', that is, a documentation of time trends in the expected...