Toluene diisocyanate (TDI), a low molecular weight reactive chemical, is known to be a main cause of occupational asthma (OA) in Korea. Although it is thought that inhaled TDI may act as a hapten, the precise mechanisms of TDI-induced OA are unknown. In this study, TDI-human serum albumin (HSA) conjugates (5, 10, 20 and 30 min) were prepared in the range of 1.5 to 5.0 TDI mole/HSA mole. Specifi...

The key pathogenic event in liver fibrosis is the activation of hepatic stellate cells (HSC). Consequently, new antifibrotic therapies are directed toward an inhibition of HSC activities. The aim of the present study was to develop a drug carrier to HSC, which would allow cell-specific delivery of antifibrotic drugs thus enhancing their effectiveness in vivo. We modified human serum albumin (HS...

High-performance affinity chromatography (HPAC) was used to examine the changes in binding that occur for the sulfonylurea drug glibenclamide with human serum albumin (HSA) at various stages of glycation for HSA. Frontal analysis on columns containing normal HSA or glycated HSA indicated glibenclamide was interacting through both high affinity sites (association equilibrium constant, K(a), 1.4-...

Purpose – In order to achieve excellence in manufacturing, goals like lean, economic and quality production with enhanced productivity play a crucial role in this competitive environment. It also necessitates major improvements in generally three primary technical areas: variation reduction, equipment reliability, and production scheduling. Complexity of the real world scheduling problems also ...

Albumin is known to have neuroprotective effects. The protein has a long half-life circulation, and its effects can therefore persist for a long time to aid in the recovery of brain ischemia. In the present study, we investigated the neuroprotective effects of human serum albumin (HSA) on brain hemodynamics. Albumin is administrated using repeated oral gavage to the rodents. Sprague-Dawley rats...

The present study describes an investigation by fluorescence quenching, circular dichroism and UV-visible spectroscopy of the interaction between norfloxacin (NRF) and human serum albumin (HSA) in the presence of electromagnetic fields (EMFs). The results obtained from this study indicated that NRF had a strong ability to quench HSA at λ(ex) = 280 nm. In addition, a slight blue shift occurred, ...

Abstract Recent studies on osteosarcoma regimens have mainly focused modifying the combination of antineoplastic agents rather than enhancing therapeutic efficacy each component. Here, an albumin nanocluster (NC)‐assisted methotrexate (MTX), doxorubicin (DOX), and cisplatin (MAP) regimen with improved antitumor is presented. Human serum (HSA) decorated thiamine pyrophosphate (TPP) to increase a...

This report used high-performance affinity microcolumns to examine the changes in binding by sulfonylurea drugs to in vivo glycated HSA that had been isolated from individual patients with diabetes. An immunoextraction approach was developed to isolate HSA and glycated HSA from clinical samples, using only 20 μL of plasma or serum and 6-12 nmol of protein to prepare each affinity microcolumn. I...

In this paper, we present a novel and efficient method for the design of a sharp, two dimensional (2D) wideband, circularly symmetric, FIR filter. First of all, a sharp one dimensional (1D) infinite precision FIR filter is designed using the Frequency Response Masking (FRM) technique. This filter is converted into a multiplier-less filter by representing it in the Canonic Signed Digit (CSD) spa...

Background: Security is widely acknowledged as a critical problem when implementing mobile ad hoc networks (MANETs) given that these networks are vulnerable to routing attacks. Although, providing authentication to the packets at each stage can reduce the risk, MANETs are still vulnerable to such attacks due to the time delay in reporting and analyzing of packets. Therefore, this problem needs ...