Maleylated bovine serum albumin is a known ligand for targeting macrophages and has potential as a carrier for molecular imaging purposes. We present a novel synthesis of glycolaldehyde-conjugated human serum albumin (GA-HSA) and maleylated human serum albumin (Mal-HSA). Seventeen modifications of fluorescently tagged GA-HSA and Mal-HSA molecules with different degrees of conjugation were prepa...

Introduction Polychlorinated biphenyls (PCBs), organic lipophilic pollutants that accumulate through diet and increase with age, have been associated polycystic ovary syndrome (PCOS) shown to affect microRNA (miRNA) expression. This work aimed determine if PCBs were circulating miRNAs whether there any correlations serum PCB/miRNA levels hormonal changes. Methods 29 non-obese PCOS healthy contr...

A new affinity method for quantification of glycated albumin by an enzyme-linked boronate-immunoassay (ELBIA) has been established, based on the interaction between boronic acids and the cis-diols of glycated human serum albumin (HSA) trapped by anti-HSA antibody. To evaluate the ELBIA, we first examined the accuracy of the conventional boronate affinity chromatographic (BAC) method. In the BAC...

Reactive oxygen intermediates (ROI) released during inflammation may act as important mediators of neutrophil effector functions. The objective of this investigation was to evaluate the influence of ROI generation on neutrophil adhesion molecule regulation and degranulation. Induction of the neutrophil oxidative burst via Fcgamma receptor cross-linking was accompanied by up-regulation of neutro...

Human serum albumin (HSA) has been used for a long time as a resuscitation fluid in critically ill patients. It is known to exert several important physiological and pharmacological functions. Among them, the antioxidant properties seem to be of paramount importance as they may be implied in the potential beneficial effects that have been observed in the critical care and hepatological settings...

Abstract Objectives Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia which caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MicroRNAs (miRNA) are small non-coding RNAs consisting 19–25 nucleotides and play role in post-transcriptional gene regulation. We have focused on serum expression levels microRNA novel concept host–virus interactions. MicroRNA profil...

Human serum albumin (HSA) reduced the phospholipid hydroperoxide, 1-palmitoyl-2-(13-hydroperoxy-cis-9, trans-11-octadecadienoyl)-l-3-phosphatidylcholine (PLPC-OOH) to the corresponding hydroxy-derivative with a high apparent affinity (Km=9. 23+/-0.95 microM). Removal of bound lipid during purification increased this activity. At physiological concentration, HSA reduced the phospholipid hydroper...

The optimal reactive power dispatch (ORPD) is a very important problem aspect of power system planning and is a highly nonlinear, non-convex optimization problem because consist of both continuous and discrete control variables. Since the power system has inherent uncertainty, hereby, this paper presents both of the deterministic and stochastic models for ORPD problem in multi objective and sin...

Introduction In gynecologic oncology, ovarian cancer is a great clinical challenge. Because of the lack typical symptoms and effective biomarkers for noninvasive screening, most patients develop advanced-stage by time diagnosis. MicroRNAs (miRNAs) are type non-coding RNA molecule that has been linked to human cancers. Specifying diagnostic determine non-cancer samples difficult. Methods By usin...

MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role...