SEE CORRESPONDING ARTICLE ON PAGE 16 TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects Monoamine Oxidase InhibitionBiological PsychiatryVol. 90Issue 1PreviewMonoamine oxidase inhibitors (MAOIs) exert therapeutic actions by elevating extracellular levels monoamines the brain. Irreversible MAOIs cause serious hypertensive crises owing to p...

BACKGROUND The monoamine hypothesis has been recognized for over half a century as a reference point to understanding electrical dysfunction associated with disease states, and/or regulatory dysfunction related to synaptic, centrally acting monoamine concentrations (serotonin, dopamine, norepinephrine, and epinephrine). METHODS Organic cation transporters (OCT) are a primary force controlling...

Leptin, a hormone produced by adipocytes, has been shown to affect a number of central functions, such as regulation of the hypothalamo-pituitary-adrenal axis, feeding, and body weight regulation. Because hypothalamic monoamines are intricately involved in the regulation of these functions, we hypothesized that leptin may produce its effects by altering the activity of these neurotransmitters. ...

Depression is one of the most common and widespread medical issues major depression also disabling all conditions. Although enormous efforts have been invested in research, there no evidence that an abnormality serotonin levels or other monoamines causes certain people are genetically predisposed to produce too little therefore experience depression. As Allen Frances, Chair Diagnostic Statistic...

Abstract Depression is one of the greatest current mental disorders. Depressive disorder may affect everyone and it causes difficulties in social functioning lead to death via suicide. a serious problem because number its cases increasing, especially after pandemic COVID-19. The oldest most approved theory which explains mechanism depression’s development monoamine hypothesis. Effectiveness ant...