Combination of a histochemical fluorescence method for biogem'c monoamines and staining of juxtaglomerular cell granules demonstrated sympathetic nerve terminals in the rat kidney in the walls of the parts of the juxtaglomerular arterioles that contain granulated cells. This forms a morphological basis for a direct influence of sympathetic nervous activity on the liberation of renin. The juxtag...

Treatment with Spinacia oleracea extract (SO; 400 mg/kg body weight) decreased the locomotor activity, grip strength, increased pentobarbitone induced sleeping time and also markedly altered pentylenetetrazole induced seizure status in Holtzman strain adult male albino rats. SO increased serotonin level and decreased both norepinephrine and dopamine levels in cerebral cortex, cerebellum, caudat...

We report an adult patient lacking endogenous synthesis of monoamines (dopamine, serotonin, and catecholamines) due to a severe dihydropteridine reductase (DHPR) deficiency. With levodopa and 5-hydroxytryptophan (5HTP) supplementation, the patient exhibited moderate mental retardation, acute episodes of parkinsonism, and episodes of depression. Despite the use of levodopa from age 3 months, he ...

The adrenergic innervation of the patent human ductus arteriosus was studied using the Falck-Hillarp fluorescent histochemical method for the localization of monoamines. Few adrenergic terminals were demonstrated in the muscular layers of the patent ductus arteriorms in 14 specimens examined. The innervation to the adventitia was sparse to moderate. The possibility that a developmental abnormal...

Norepinephrine, dopamine, and serotonin concentrations in the hypothalamus and stalk-median eminence were estimated in nine Hereford heifers at the onset of oestrus or 48 hr later. Significant differences in levels of monoamines at these stages of the oestrous cycle were not evident. Norepinephrine levels were similar in the hypothalamus and the stalk-median eminence, but dopamine and serotonin...

1. Inactivation of beta-phenylethylamine and several of its derivatives was studied in a preparation of rabbit lung perfused with Krebs physiological medium at 37 degrees C. Inactivation or removal of these compounds was calculated as the difference between the concentration of each amine in the perfusion medium and the effluent, collected separately from each lung. The extent of amine metaboli...

Introduction There is much empirical support for the notion that acetylcholine (ACh) and the monoamine neurotransmitters noradrenaline (NA), dopamine (DA) and serotonin (5-HT) modulate cognitive processes (including attention, learning and memory, executive control and decision-making) in specific and distinct ways. The application of in-vivo brain microdialysis in closely controlled behavioura...

Most work in the neurochemistry of anxiety has focused on the monoamines 5-HT and NA, the GABA-benzodiazepine (BDZ) receptor complex and a number of unrelated challenge compounds that are known to provoke anxiety and/or panic (e.g. cholecystokinin, sodium lactate, caffeine) . Interest in the GABAergic; 5-HTergic and NAergic systems originates from the clinical efficacy of compounds affecting th...