Combination of a histochemical fluorescence method for biogem'c monoamines and staining of juxtaglomerular cell granules demonstrated sympathetic nerve terminals in the rat kidney in the walls of the parts of the juxtaglomerular arterioles that contain granulated cells. This forms a morphological basis for a direct influence of sympathetic nervous activity on the liberation of renin. The juxtag...

l. Studies using clorgyline, deprenyl and semicarbazide as inhibitors showed that carp heart homogenate contained a new type of monoamine oxidase (MAO) and a clorgylineand deprenyl-resistant amine oxidase (CRAO). 2. The deamination of monoamines by carp heart MAO proceeded in two steps by a doubledisplacement (ping-pong) mechanism. 3. The rC, values of the MAO for oxygen (K, values) with tyrami...

Responses to monoamines perfused over the cortical surface through modified pial windows were monitored in 106 cats. Norepinephrine (NE) and serotonin (5-HT) were diluted in mock CSF to concentrations of 50 and 500 ng/ml respectively, levels at or near the maximum concentrations to which the cortical surface might be exposed in subarachnoid hemorrhage or damage to nearby neurons. Each cat had s...

It has been reported that timiperone, a new butyrophenone, 4'-fluoro-4-[4-(2thioxo -1-benzimidazolynyl) piperidino] butyrophenone, possesses potent antipsychotic activity (Yamasaki et al. 1977; Sato et al. 1978). Tachizawa and co-workers (1979), using a 3 H -spiroperidol binding assay, showed that timiperone inhibited specific 3 H spiroperidol binding in vitro at low concentrations similarly to...

.......................................................................................................................................... i Executive Summary...................................................................................................................... ii 1.0 Basis for Nomination ...............................................................................................